Results 101 to 110 of about 15,660 (211)

ClusterCAD: a computational platform for type I modular polyketide synthase design [PDF]

, 2017
ClusterCAD is a web-based toolkit designed to leverage the collinear structure and deterministic logic of type I modular polyketide synthases (PKSs) for synthetic biology applications.
Backman, Tyler W. H., Bailey, Constance B., Baldi, Pierre, Eng, Clara H., Katz, Leonard, Keasling, Jay D., Magnan, Christophe, Martin, Hector Garcia   +7 more
core   +2 more sources

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, EarlyView.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea

New Microbes and New Infections, 2017
We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia, A. Caputo, F. Djossou, D. Raoult   +3 more
doaj   +1 more source

Secondary metabolites in Gerbera hybrida [PDF]

, 2008
Plants produce a diversity of secondary metabolites, i.e., low-molecular-weight compounds that have primarily ecological functions in plants. The flavonoid pathway is one of the most studied biosynthetic pathways in plants.
Ainasoja, Miia
core  

Evolutionary distinctiveness of fatty acid and polyketide synthesis in eukaryotes [PDF]

, 2016
© 2016 International Society for Microbial Ecology All rights reserved. Fatty acids, which are essential cell membrane constituents and fuel storage molecules, are thought to share a common evolutionary origin with polyketide toxins in eukaryotes.
A Fiebig, A Ianora, A Marchler-Bauer, A Stamatakis, A Stüken, AA Millar, AA Millar, AD Cembella, AZ Worden, B Gajria, B Imanian, BA Read, C Khosla, CB Field, CG Jones, CJ Gobler, DE Cane, DG Baden, EA Monroe, EV Armbrust, Frances M Van Dolah, G Zhu, GI McFadden, GI McFadden, GM Hallegraeff, GM Hallegraeff, GS Kohli, Gurjeet S Kohli, H Jenke-Kodama, H Zhang, H-J Kwon, HS Yoon, I Letunic, J Felsenstein, J Janouškovec, J Kroymann, J-K Weng, JA Kalaitzis, JD Hackett, JD Thompson, JH Wisecaver, JM Cock, JM Meyer, K Eichholz, K Katoh, K Ryall, K Tamura, L Kunst, LW Parfrey, M Chinain, M Freitag, M Kearse, M Punta, MJ Gardner, O Deusch, O Emanuelsson, PJ Keeling, PJ Keeling, R Pawlowiez, RD Finn, RD Firn, RF Waller, RJS Orr, SA Murray, SA Murray, Shauna A Murray, SW White, T Bayer, T Salcedo, TM Dunn, TR Bachvaroff, U John, U John, Uwe John, V Smetacek, W Martin, W Martin, WR Riekhof   +77 more
core   +2 more sources

Multi‐Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rheum tanguticum is renowned for its medicinal properties, including purgative, anti‐inflammatory and hepatoprotective effects, primarily attributed to anthraquinones (AQs). However, the molecular mechanisms of AQs biosynthesis have largely been hindered by insufficient genomic resources and functional genomics investigations.
Shuo Zhao, Yuan Zong, Tao Wang, Jianan Li, Zengrong Ye, Famei Zhang, Guoying Zhou   +6 more
wiley   +1 more source

Strategies in megasynthase engineering – fatty acid synthases (FAS) as model proteins

Beilstein Journal of Organic Chemistry, 2017
Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds by catalyzing the successive condensation and modification of precursor units.
Manuel Fischer, Martin Grininger
doaj   +1 more source

The genome of the insecticidal Chromobacterium subtsugae PRAA4-1 and its comparison with that of Chromobacterium violaceum ATCC 12472

Genomics Data, 2016
The genome of Chromobacterium subtsugae strain PRAA4-1, a betaproteobacterium producing insecticidal compounds, was sequenced and compared with the genome of C. violaceum ATCC 12472. The genome of C.
Michael B. Blackburn, Michael E. Sparks, Dawn E. Gundersen-Rindal   +2 more
doaj   +1 more source

Genome-based natural product biosynthetic gene cluster discovery : from sequencing to mining [PDF]

, 2014
Natural products are small molecules produced by a range of living organisms. They may be toxic or have pharmaceutical applications as antibiotics, anticancer, antiparasitic and anti-fungal agents.
Wang, Hao
core  

A photoactivatable small molecule probe for the in vivo capture of polyketide intermediates [PDF]

, 2019
A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation.
Jenkins, Robert, Kilgour, Samantha Louise, Tosin, Manuela   +2 more
core   +1 more source