Results 131 to 140 of about 15,660 (211)

Dereplicative Combination of HPLC/DAD/MS and 2D NMR to Identify Lichexanthone Isomers in Lichen Extracts

Phytochemical Analysis, Volume 37, Issue 2, Page 330-343, March 2026.
ABSTRACT Introduction Lichexanthones are the major xanthones found in lichens. They present a high degree of isomerism, which makes their identification tedious. Xanthones are known to occur in lichens according to chemosyndromes, and these compounds act as chemotaxonomic markers.
Solenn Ferron, Marylène Chollet‐Krugler, Hermann Pinson, Rania Marzoug, Philippe Uriac, Françoise Lohézic‐Le Dévéhat   +5 more
wiley   +1 more source

Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo, Aurora Martín, Mateo Jácome, Xia Wan, María Lucas, Gabriel Moncalián   +5 more
wiley   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

Small, Volume 22, Issue 16, 17 March 2026.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1359-1376, March 2026.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

Insights into glandular trichome biology from analysis of organ‐specific gene expression programmes in cannabis, hop and tomato

The Plant Journal, Volume 125, Issue 6, March 2026.
Significance Statement This study of three glandular trichome‐producing species (cannabis, hop and tomato) defines tissue‐specific transcriptomic atlases for five organs (trichome, flower, leaf, stem and root), providing co‐expression and gene regulatory networks and identifying candidate regulators of specialised metabolism in trichomes of each ...
Muluneh Tamiru‐Oli, Bhavna Hurgobin, Oliver Berkowitz, Lingling Yin, Ricarda Jost, Sofya Gvaramiya, Matthew Welling, Monika S. Doblin, Antony Bacic, James Whelan, Mathew G. Lewsey   +10 more
wiley   +1 more source

Isolation of a polyketide synthase gene from Dothistroma pini : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University, Palmerston North, New Zealand [PDF]

, 1997
Dothistromin is a polyketide derived mycotoxin, produced by Dothistroma pini, which is structurally related to aflatoxins produced by Aspergillus parasiticus and Aspergillus flavus. Southern blot analysis of D.
Morgan, Branwen
core  

Animal FAS-like polyketide synthases produce diverse polypropionates. [PDF]

Proc Natl Acad Sci U S A, 2023
Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt EW.   +5 more
europepmc   +1 more source

Polyketide synthases mutation in tuberculosis transmission revealed by whole genomic sequence, China, 2011-2019. [PDF]

Front Genet, 2023
Wang TT, Hu YL, Li YF, Kong XL, Li YM, Sun PY, Wang DX, Li YY, Zhang YZ, Han QL, Zhu XH, An QQ, Liu LL, Liu Y, Li HC.   +14 more
europepmc   +1 more source

Biosensor Guided Polyketide Synthases Engineering for Optimization of Domain Exchange Boundaries. [PDF]

Nat Commun, 2023
Englund E, Schmidt M, Nava AA, Klass S, Keiser L, Dan Q, Katz L, Yuzawa S, Keasling JD.   +8 more
europepmc   +1 more source

A CRISPR-Cas9 system for knock-out and knock-in of high molecular weight DNA enables module-swapping of the pikromycin synthase in its native host

Microbial Cell Factories
Background Engineers seeking to generate natural product analogs through altering modular polyketide synthases (PKSs) face significant challenges when genomically editing large stretches of DNA.
Zhe-Chong Wang, Hayden Stegall, Takeshi Miyazawa, Adrian T. Keatinge-Clay   +3 more
doaj   +1 more source