Results 11 to 20 of about 15,660 (211)
The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
Molecules, 2011 Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis.
David H. Kwan, Frank Schulz
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Evolutionary Histories of Type III Polyketide Synthases in Fungi [PDF]
Frontiers in Microbiology, 2020 Type III polyketide synthases (PKSs) produce secondary metabolites with diverse biological activities, including antimicrobials. While they have been extensively studied in plants and bacteria, only a handful of type III PKSs from fungi has been ...
Jorge Carlos Navarro-Muñoz +1 more
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Engineering Polyketide Synthases [PDF]
The Scientific World Journal, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
Leonard Katz
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C–N bond formation by a polyketide synthase
Nature Communications, 2023 Assembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we present the cryo-EM
Jialiang Wang +14 more
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The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]
, 2012 There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Amy J. Gerc +5 more
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Synthetic biology of polyketide synthases [PDF]
Journal of Industrial Microbiology and Biotechnology, 2018 Abstract Complex reduced polyketides represent the largest class of natural products that have applications in medicine, agriculture, and animal health. This structurally diverse class of compounds shares a common methodology of biosynthesis employing modular enzyme systems called polyketide synthases (PKSs).
Yuzawa, Satoshi +3 more
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Nature Communications, 2020 Several different genetic strategies have been reported for the modification of polyketide synthases but the highly repetitive modular structure makes this difficult.
Kei Kudo +10 more
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Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
Nature Communications, 2022 Genetic engineering of the type I polyketide synthases (PKSs) to produce desirable analogous remains largely inefficient. Here, the authors leverage multiple approaches to delete seven internal modules from the stambomycin PKS and generate 37-membered ...
Li Su +8 more
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Metabolic Engineering Communications, 2020 Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical ...
Kai P. Yuet, Chaitan Khosla
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Decrypting the programming of β-methylation in virginiamycin M biosynthesis
Nature Communications, 2023 Biosynthesis of complex polyketides by polyketide synthases often relies on trans-acting enzymes to modify the intermediates. Here, the authors elucidate how β-methylation enzymes identify their substrates.
Sabrina Collin +6 more
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