Results 41 to 50 of about 15,660 (211)

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. [PDF]

, 2017
Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular ...
Alanine, Alexander, Alt, Silke, Carter, Guy T, Chao, Suzan Keen, Coates, Nigel J, Graziani, Edmund I, Gregory, Matthew A, Heine, Daniel, Higginbotham, Sarah J, Hold, Adam, Kendrew, Steve G, Koehn, Frank E, Leadlay, Peter F, Martin, Christine J, McDonald, Leonard, Moss, Steven J, Norville, Isobel H, Nur-E-Alam, Mohammad, Overvoorde, Lois, Pogwizd, Joanna, Radzom, Markus, Ratni, Hasane, Rodríguez Sarmiento, Rosa María, Rudder, Steven, Samborskyy, Markiyan, Sarkar-Tyson, Mitali, Sheehan, Lesley S, Stanley-Smith, Anna E, Steward, Lucinda, Warneck, Tony, Wilkinson, Barrie, Wlodek, Aleksandra   +31 more
core   +2 more sources

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]

Angewandte Chemie International Edition, 2018
AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel   +6 more
openaire   +3 more sources

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases [PDF]

, 2014
Type I modular polyketide synthases (PKSs), responsible for the biosynthesis of many biologically active agents, possess a ketosynthase (KS) domain within each module to catalyze chain elongation. Acylation of the KS active site Cys residue is followed
Afonso, José Pedro, Bailey, Hannah R., Frank, Sarah, Jenner, Matthew, Kampa, Annette, Oldfield, Neil J., Piel, Jörn   +6 more
core   +2 more sources

New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

Molecules, 2021
In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile.
Constanze Paulus, Oleksandr Gromyko, Andriy Luzhetskyy   +2 more
doaj   +1 more source

Functional characterization and expression of GASCL1 and GASCL2, two anther-specific chalcone synthase like enzymes from Gerbera hybrida [PDF]

, 2017
The chalcone synthase superfamily consists of type III polyketidesynthases (PKSs), enzymes responsible for producing plant secondary metabolites with various biological and pharmacological activities. Anther-specific chalcone synthase-like enzymes (ASCLs)
Albert, Victor A., Bashandy, Hany, Deng, Xianbao, Kontturi, Juha, Osama, Raisa, Teeri, Teemu H.   +5 more
core   +1 more source

Evolutionary Implications of Bacterial Polyketide Synthases [PDF]

Molecular Biology and Evolution, 2005
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of pharmaceutical properties, including antibiotic, antitumor, antifungal, and immunosuppressive activities. We have performed a comprehensive phylogenetic analysis
Holger, Jenke-Kodama, Axel, Sandmann, Rolf, Müller, Elke, Dittmann   +3 more
openaire   +2 more sources

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P [PDF]

, 2017
Genome mining of the mithramycin producer Streptomyces argillaceus ATCC 12956 revealed 31 gene clusters for the biosynthesis of secondary metabolites, and allowed to predict the encoded products for 11 of these clusters.
Alfredo F. Braña, Brian Molloy, Carlos Olano, Carmen Méndez, Daniel Zabala, Francisco Morís, Jesús Cortés, José A. Salas, Suhui Ye   +8 more
core   +4 more sources

Evidence for a Structural Role for Acid-Fast Lipids in Oocyst Walls of Cryptosporidium, Toxoplasma, and Eimeria [PDF]

, 2013
Coccidia are protozoan parasites that cause significant human disease and are of major agricultural importance. Cryptosporidium spp. cause diarrhea in humans and animals, while Toxoplasma causes disseminated infections in fetuses and untreated AIDS ...
Aurrecoechea, Beisson, Belli, Buda, Bushkin, Cai, Chapman, Chatterjee, Chiang, Drummond, Dubey, Ferguson, Garcia, Gulder, Hein, Hendry, Johnston, Kotloff, Layre, Lesage, Mai, Mauzy, Mohanty, Portevin, Possenti, Quittnat, Ramakrishnan, Remmal, Samuelson, Striepen, Weiss, Yamada, Zhu   +32 more
core   +1 more source

Structure of a modular polyketide synthase [PDF]

Nature, 2014
Polyketide natural products constitute a broad class of compounds with diverse structural features and biological activities. Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear extensions and keto-group processing reactions on intermediates ...
Dutta, Somnath, Whicher, Jonathan R., Hansen, Douglas A., Hale, Wendi A., Chemler, Joseph A., Congdon, Grady R., Narayan, Alison R., Håkansson, Kristina, Sherman, David H., Smith, Janet L., Skiniotis, Georgios   +10 more
openaire   +2 more sources