Results 161 to 170 of about 27,763 (265)

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

From Pigment Chemistry to Nanomaterials: Fungal Pigments as Reducing and Stabilizing Agents in Green Nanoparticle Synthesis. [PDF]

Microorganisms
Chavan A, Mavlankar G, Kakde UB, Dufossé L, Deshmukh SK.   +4 more
europepmc   +1 more source

Deciphering the biosynthetic pathways of lichen acids

New Phytologist, Volume 250, Issue 3, Page 1784-1799, May 2026.
Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Wonyong Kim, Tânia Keiko Shishido, Huong T. Pham, Kyo Bin Kang, Rundong Liu, Matti Wahlsten, Jérôme Collemare, Hyun Park, Soon‐Ok Oh, Hyung‐Ho Ha, Hangun Kim, Jae‐Seoun Hur   +11 more
wiley   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +2 more sources

Phytochemical Composition, Antioxidant and Anti-Inflammatory Activities, and Protective Effect Against LPS-Induced Liver Injury in Mice of Gerbera delavayi Franch. [PDF]

Antioxidants (Basel)
Yin H, Zhao Y, Hu R, Yang J, Chen Y, Tang H, Li X, Ye G, Shi F, Lv C, Zhao L.   +10 more
europepmc   +1 more source

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range

New Phytologist, Volume 250, Issue 3, Page 1863-1883, May 2026.
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle   +39 more
wiley   +1 more source

Peniexpansones A-F: polyketides from Penicillium expansum DWS880 capable of enhancing the activity of fluconazole against Candida albicans. [PDF]

Nat Prod Bioprospect
Lu WY, Xiao QH, Liang AL, Xu PJ, Li J, Wang WX.   +5 more
europepmc   +1 more source

Beneficial rhizobacteria and virus infection modulate the soybean metabolome and influence the feeding preferences of the virus vector Epilachna varivestis

New Phytologist, Volume 250, Issue 4, Page 2599-2618, May 2026.
Summary Beneficial rhizobacteria and viral pathogens can both alter host plant phenotypes, yet little is known about how their simultaneous presence influences plant metabolism and species interactions. We investigated how two rhizobacteria, Bradyrhizobium japonicum and Delftia acidovorans, together with bean pod mottle virus (BPMV), shape soybean ...
Hannier Pulido, Kerry E. Mauck, Consuelo M. De Moraes, Mark C. Mescher   +3 more
wiley   +1 more source

Editorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals

Frontiers in Microbiology, 2023
Weiyi Wang, Ting-Ting Wang
doaj   +1 more source

Covalent warhead assembly in fostriecin biosynthesis involves malonylation-lactonisation by a bifunctional thioesterase and enzymatic demalonylation. [PDF]

Nat Commun
Nguyen LNKT, Schlotte L, Hoffmann J, Betz D, Schröder M, Hahn F.   +5 more
europepmc   +1 more source