Results 41 to 50 of about 267,439 (289)

Polymeric Micelle Systems for Oral Drug Delivery of Small Molecule Therapeutics

Pharmaceutics
Oral administration remains the most convenient and favored route for systemic delivery of small-molecule drugs, primarily due to patient compliance and the absence of invasive procedures. Yet, poor aqueous solubility, chemical/enzymatic instability, and
Eungyeop Lee, Jum Bum Kwon, Hyuk Jun Cho, Mi Ran Woo, Dong Wuk Kim, Jong Oh Kim, Duhyeong Hwang   +6 more
doaj   +1 more source

Pharmacokinetic Evaluation of a DSPE-PEG2000 Micellar Formulation of Ridaforolimus in Rat

Pharmaceutics, 2012
The rapamycin analog, ridaforolimus, has demonstrated potent anti-proliferative effects in cancer treatment, and it currently is being evaluated in a range of clinical cancer studies. Ridaforolimus is an extremely lipophilic compound with limited aqueous
Marcus Laird Forrest, Yunqi Zhao, Jody K. Takemoto, Rebecca M. Bertram, Connie M. Remsberg, Neal M. Davies   +5 more
doaj   +1 more source

Multifunctional Polymeric Micelles for Cancer Therapy

Polymers, 2022
Polymeric micelles, nanosized assemblies of amphiphilic polymers with a core–shell architecture, have been used as carriers for various therapeutic compounds. They have gained attention due to specific properties such as their capacity to solubilize poorly water-soluble drugs, biocompatibility, and the ability to accumulate in tumor via enhanced ...
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy   +2 more
openaire   +2 more sources

Linking Polyelectrolyte Modification and Enzyme‐Catalyzed Phenolic Acid Functionalization of Cellulose Fiber for Functional Foams

Advanced Materials Technologies, EarlyView.
Cellulose fibers functionalized using cationic poly(Dimethyldiallylammonium chloride) (polyDADMAC) and laccase‐mediated ferulic acid system are processed into foams using different surfactants (Anionic, cationic, and non‐ionic). Fiber–surfactant interactions influence foam stabilization and porous structure formation during convective drying, producing
Abirami Senthil, Sara Wallstén, Paul Christakopoulos, Ulrika Rova, Io Antonopoulou   +4 more
wiley   +1 more source

Polymeric micelles for acyclovir drug delivery [PDF]

Colloids and Surfaces B: Biointerfaces, 2014
Polymeric prodrug micelles for delivery of acyclovir (ACV) were synthesized. First, ACV was used directly to initiate ring-opening polymerization of ɛ-caprolactone to form ACV-polycaprolactone (ACV-PCL). Through conjugation of hydrophobic ACV-PCL with hydrophilic methoxy poly(ethylene glycol) (MPEG) or chitosan, polymeric micelles for drug delivery ...
Alicia J, Sawdon, Ching-An, Peng
openaire   +2 more sources

Dual temperature- and pH-responsive polymeric micelle for selective and efficient two-step doxorubicin delivery

, 2017
Dual responsive polymeric micelle enabled selective intracellular uptake with thermal stimulation and effective release of doxorubicin at acidic endosomal pH.
Naoya Katsuyama, Yuki Kanda, Hideko Kanazawa, Yuki Hiruta   +3 more
core   +1 more source

Drug Release Profile and Cellular Uptake of Polymeric Prodrugs Synthesized from Amphiphilic Blockcopolymer Using Mechanically Produced Macromonomers Possessing Anhydrate as a Terminal Group [PDF]

, 2016
In this paper, the polymeric micelle was fabricated with amphiphilic block copolymer which was synthesized by the condensation of mechanochemically produced PBzMA macromonomer with a-methyl-w-aminopropoxy polyoxyethylene.
Sayaka Kimura, Kenjiro Tatematsu, Shin-ichi Kondo, Yuka Sawama, Yukinori Yamauchi, Yasushi Sasai, Masayuki Kuzuya, Naoki Doi, Sayaka Kimura, Kenjiro Tatematsu, Yuka Sawama, Shin-ichi Kondo, Naoki Doi   +12 more
core   +1 more source

Polymeric micelle as a nanocarrier for delivery of therapeutic agents: A comprehensive review [PDF]

, 2020
For selective and effective drug delivery of therapeutic agent nanocarriers are the most effective agents. Micelles are an aggregate of surfactant molecules that dispersed in a liquid colloid.
Agrawal, Roshani D., Rarokar, Nilesh R., Umekar, Milind J., Tatode, Amol A.   +3 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen

Nanoscale Research Letters, 2009
A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a promising anticancer drug ethaselen.
Yang Zhuoli, Ren Lijun, Yang Kewei, Li Xinru, Zhou Yanxia, Chen Xingwei, Zhang Yanhui, Wang Fei, Liu Yan   +8 more
doaj   +1 more source