Results 61 to 70 of about 267,439 (289)
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
A Scalable Spin‐Coating Strategy for Mesoporous Gold Thin Films toward miRNA Detection
Advanced Science, EarlyView.A scalable spin‐coating strategy produces uniform mesoporous Au thin films with tunable thickness and high electroactive surface area on transparent substrates. The resulting architecture enables label‐free, amplification‐free detection of ovarian cancer‐associated miRNA hsa‐miR‐200c‐3p from 1 aM to 10 pM, achieving a 1.72 aM detection limit with high ...
Aditya Ashok +8 more
wiley +1 more source
Drug Delivery, 2019 Myricetin (Myr) is a naturally occurring flavonoid exhibiting diverse biological and pharmacological properties, but its characteristics such as water insolubility, poor aqueous stability, and poor bioavailability limit its clinical application ...
Fengyuan Sun +6 more
doaj +1 more source
Neutral Polymeric Micelles for RNA Delivery [PDF]
Bioconjugate Chemistry, 2013 RNA interference (RNAi) drugs have significant therapeutic potential, but delivery systems with appropriate efficacy and toxicity profiles are still needed. Here, we describe a neutral, ampholytic polymeric delivery system based on conjugatable diblock polymer micelles. The diblock copolymer contains a hydrophilic poly[N-(2-hydroxypropyl)methacrylamide-
Brittany B, Lundy +3 more
openaire +2 more sources
, 2021 Tumor microenvironment (TME) responsive polymeric micelles are promising carriers for drug delivery. In order to meet the needs of various applications, multifarious TME-responsive switches are used to construct smart polymeric micelles, which causes the
Nanxia Zhang (11377866) +17 more
core +1 more source
Advanced Science, EarlyView.Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li +6 more
wiley +1 more source
, 2017 Pharmacokinetic parameters of carfilzomib after the intravenous administration of polymeric micelle formulation containing carfilzomib (CFZ-PM) and cyclodextrin-based carfilzomib formulation (CFZ-CD) to ICR mice.
Heon-Min Ryu (3821398) +14 more
core +1 more source
Advanced Science, EarlyView.A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang +10 more
wiley +1 more source
Micellization model for the polymerization of clathrin baskets [PDF]
The Journal of Chemical Physics, 2013 A thermodynamic model is used to investigate the conditions under which clathrin triskelions form polyhedral baskets. The analysis, which is similar to classical methods used to study micelle formation, relates clathrin basket energetics to system parameters linked to triskelial rigidity, the natural curvature of an isolated triskelion, and ...
M, Muthukumar, Ralph, Nossal
openaire +2 more sources
Experimental Design, Synthesis and Application of Molecular Micelle Modified Polymeric Nanoparticles for Drug Delivery Systems and Free Radical Detection [PDF]
, 2009 Biodegradable and biocompatible polymeric nanoparticles such as poly (lactide-co-glycolide) (PLGA) nanoparticles have been extensively studied as drug delivery systems for a variety of pharmaceutical agents.
Ganea Visser, Gabriela M. +2 more
core +1 more source