Results 111 to 120 of about 20,043 (225)

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

open access: yesAdvanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man   +7 more
wiley   +1 more source

Conformational analysis of nucleic acids revisited: Curves+ [PDF]

open access: yes, 2017
We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones.
Lavery, R.   +4 more
core  

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

open access: yesChemistryEurope, Volume 4, Issue 2, February 2026.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao   +4 more
wiley   +1 more source

Association between polymorphism in myostatin gene (MSTN) with quantitative traits in domesticated rainbow trout (Oncorhynchus mykiss) using PCR-SSCP method

open access: yes‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2016
In this study the rainbow trout (Oncorhynchus mykiss) myostatin gene (MSTN) for detecting gene derived SNPs and performing genetic association study between MSTN polymorphisms and growth traits were analyzed.
S.Nazari
doaj  

Sensitive electrochemical assays of DNA structure [PDF]

open access: yes, 2009
Electrochemical methods have been used to study the structure and function of nucleic acids for more than 50 years. These approaches complement other experimental techniques, which we illustrate by using examples from studies of processes involved in the
Bowater, RP   +3 more
core  

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications

open access: yesCurrent Protocols, Volume 6, Issue 2, February 2026.
Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley   +1 more source

Mechanochemical Treatment of Cellulose: A Strategy for Developing Functional Biocomposite Materials

open access: yesPolymer Engineering &Science, Volume 66, Issue 2, Page 662-688, February 2026.
Mechanochemistry as an integrated approach for combining fiber defibrillation, activation, surface functionalization, and cellulose‐based composite fabrication in a single or reduced number of steps. ABSTRACT Cellulose‐based biocomposites are attracting increasing scientific and industrial interest due to their sustainable origin, biodegradability, and
Murilo O. da Luz   +3 more
wiley   +1 more source

Determination of human cytomegalovirus genetic diversity in different patient populations in Costa Rica

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2004
Seroprevalence of HCMV in Costa Rica is greater than 95% in adults; primary infections occur early in life and is the most frequent congenital infection in newborns.
Sara Ahumada-Ruiz   +4 more
doaj  

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast

open access: yesProtein Science, Volume 35, Issue 2, February 2026.
Abstract The misfolding and aggregation of α‐synuclein is a central molecular event in the etiology of Parkinson's disease and related disorders. α‐synuclein misfolding and pathology are both concentration‐dependent, but it is not clear precisely how changes in concentration alter the folding landscape within cells. Whereas most conventional structural
Daeun Noh, Robert W. Newberry
wiley   +1 more source

Associations of sociodemographic, clinical factors and HLA-B alleles with enthesitis and peripheral arthritis in patients with ankylosing spondylitis

open access: yesRMD Open
Objectives Factors associated with peripheral arthritis and enthesitis, especially Achilles tendonitis and plantar fasciitis, were examined in a longitudinal cohort of 1075 patients with ankylosing spondylitis (AS) (also known as radiographic axial ...
Michael H Weisman   +10 more
doaj   +1 more source

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