Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter +4 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Diversity of MHC-B SNP haplotypes in the Vietnamese Ri chicken. [PDF]
J Anim Sci TechnolNam S +7 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon +18 more
wiley +1 more source
Correction: Single Nucleotide Polymorphism Analysis of European Archaeological DNA.
PLoS ONE, 2010 Claire L. Watson +4 more
doaj +1 more source
Genetic variations in amino acid metabolism-related genes are associated with risk of papillary thyroid carcinoma: a case-control study. [PDF]
BMC Endocr DisordMeng H, Xiao Z, Wang Q, Li D, Li Z.
europepmc +1 more source
Transforming Pharmacovigilance With Pharmacogenomics: Toward Personalized Risk Management
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacovigilance is a critical component of medication safety. Despite rigorous evaluation of new drugs during clinical trials, some adverse effects might only be identified once pharmaceuticals are used by a larger population for a longer duration.
Claire Spahn +8 more
wiley +1 more source
Association of <i>FAM13A</i> single-nucleotide polymorphism with spirometry indices and pulmonary ventilation characteristics in patients with chronic obstructive pulmonary disease. [PDF]
J Int Med ResNguyen BH +8 more
europepmc +1 more source
Intestinal Barrier Glycosylation for Gut Physiology and Pathology
Barrier Immunity, EarlyView.ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley +1 more source
An Integrative Analysis of O6-Methylguanine-DNA Methyltransferase (MGMT) Methylation and the Single-Nucleotide Polymorphism (SNP) rs1625649 Reveals Distinct Survival Patterns in Glioblastoma: A Retrospective Study. [PDF]
CureusAgarwal K +6 more
europepmc +1 more source