Results 201 to 210 of about 900,745 (376)

UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia

Annals of Neurology, EarlyView.
UNC13A (rs12608932‐CC) is associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and shortens survival in ALS. We aim to describe the association for UNC13A and survival in FTD. We included 626 patients with FTD from Dutch memory clinics, including a subcohort of 150 patients with TDP‐43 pathology. Survival analyses
Lianne M. Reus, Sean W. Willemse, Sterre C.M. de Boer, Julie De Houwer, Willem L. Hartog, Merel O. Mol, Jeroen G. J. van Rooij, Niccolo Tesi, Laura Donker Kaat, Marc Hulsman, Everard G. B. Vijverberg, Henne Holstege, Wouter van Rheenen, Jan H. Veldink, Leonard H. van den Berg, John C. van Swieten, H. Seelaar, Sven J. van der Lee, Michael A. van Es, Yolande A. L. Pijnenburg   +19 more
wiley   +1 more source

Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason, Charles C. T. Hindmarch, Kimberly J. Dunham‐Snary   +2 more
wiley   +1 more source

Evidence for convergent nucleotide evolution and high allelic turnover rates at the complementary sex determiner (csd) gene of western and Asian honey bees [PDF]

, 2008
Our understanding of the impact of recombination, mutation, genetic drift and selection on the evolution of a single gene is still limited. Here we investigate the impact of all of these evolutionary forces at the complementary sex determiner (csd) gene ...
Beye, Martin, Hasselmann, Martin, Koeniger, Gudrun, Koeniger, Nikolaus, Pflugfelder, Jochen, Tingek, Salim, Vekemans, Xavier   +6 more
core   +1 more source

The ATM Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and is an Attractive Candidate for Medicinal Chemistry Optimisation Ag…

Angewandte Chemie International Edition, Accepted Article.
New compounds targeting human malaria parasites are critical for effective malaria control and elimination. Here, we pursued the imidazoquinolinone AZD0156 (MMV1580483), a human ataxia‐telangiectasia mutated (ATM) kinase inhibitor that completed Phase I clinical trials as an anticancer agent.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Gibhard, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn-Marié Birkholtz, Kelly Chibale   +33 more
wiley   +1 more source

Evaluation of ABCA1 gene polymorphism as a prognostic index of fibrosis progression in NAFLD patients

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Dyslipidemias, hepatic steatosis index, and ABCA1 (rs1800977) gene polymorphism CC genotype; were the only independent predictors of advanced fibrosis in NAFLD‐patients. Abstract Introduction It had been evident that non‐alcoholic fatty liver disease (NAFLD) is the new era epidemic.
Samar E. Ghanem, Maha M. Elsabaawy, Mervat M. Abdelkareem, Marwa L. Helal, Warda Othman, Mahitab Elsayed, Dalia M. Elsabaawy, Ashraf El Fert   +7 more
wiley   +1 more source

Honey Bee Breeding and Breed: Advancements, Challenges, and Prospects

Animal Research and One Health, EarlyView.
Our work clarifies concepts related to honey bee classification, reviews traditional and modern breeding techniques, explores advancements in molecular breeding, prospects gene‐editing tools, and advocates for integrated breeding strategies to ensure the long‐term sustainability and vitality of honey bee populations amid declining managed populations ...
Zheguang Lin, Lizhi Yang, Zhi Wang, Kang Wang, Qingsheng Niu, Ting Ji   +5 more
wiley   +1 more source

Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics[S]

Journal of Lipid Research, 2011
To identify genetic loci influencing blood lipid levels in Caribbean Hispanics, we first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein
Chuanhui Dong, Ashley Beecham, Liyong Wang, Susan Slifer, Clinton B. Wright, Susan H. Blanton, Tatjana Rundek, Ralph L. Sacco   +7 more
doaj  

Genomic Insights Into the Population and Antibiotic Resistance Changes of Salmonella Pullorum in China

Animal Research and One Health, EarlyView.
Salmonella Pullorum strains in China are categorized into three phylogenetic clades. Clade 1 strains have all been isolated in the past 15 years. The population size of S. pullorum in China saw a significant decline between 2003 and 2016, reflecting the effectiveness of purification efforts.
Ke Wu, Jie Zhang, Jing Zuo, Qian Chen, Honglin Peng, Changwei Lei, Hongning Wang   +6 more
wiley   +1 more source

Single-nucleotide polymorphism-based genetic risk score and patient age at prostate cancer diagnosis [PDF]

, 2019
Importance: Few studies have evaluated the association between a single-nucleotide polymorphism-based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis.
Andriole, Gerald L, Fantus, Richard J, Helfand, Brian T, Isaacs, William B, Labbate, Craig, Na, Rong, Shi, Zhuqing, Wang, Chi-Hsiung, Xu, Jianfeng, Yu, Hongjie, Zheng, S Lilly   +10 more
core   +1 more source

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

Animal Research and One Health, EarlyView.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao, Chenxi Zhang, Kaiyuan Tian, Shucan Zhao, Yongle Xue, Sensen Yan, Chengpeng Xiao, Donghua Li, Guirong Sun, Ruili Han, Ruirui Jiang, Yadong Tian, Wenting Li, Kejun Wang, Xiangtao Kang   +14 more
wiley   +1 more source