Results 211 to 220 of about 690,386 (352)

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, EarlyView.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Genome-Wide Meta-Analysis Identifies Five Single-Nucleotide Polymorphisms Associated With Both Vitiligo and Freckles in the Chinese Han Population. [PDF]

J Cosmet Dermatol
Lu J, Wang Y, Li Z, Yu J, Song C, Wang M, Yan S, Du J, Liu C, Guo X, Feng X, Niu W, Lv M, Chen W, Han Y, Zhen Q, Sun L.   +16 more
europepmc   +1 more source

Comparative Effectiveness of Abatacept versus Adalimumab in Shared Epitope positive and negative Rheumatoid Arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives The effect of the shared epitope (SE), and valine at position 11 (Val11) of HLA‐DRB1, on the activation of CD4+ T cells, is expected to be diminished by abatacept, a co‐stimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting.
Chuan Fu Yap, Nisha Nair, Seema D Sharma, John Bowes, Amirah Binti Mohammad Ariff, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme L Hyrich, Suzan Verstappen, James Bluett, Andrew P Morris, Anne Barton, Darren Plant, Sebastien Viatte   +14 more
wiley   +1 more source

Single Nucleotide Polymorphisms in APE1, hOGG1, RAD51 Genes and Radiotherapy Induced Toxicity among Head and Neck Cancer Patients: Comment. [PDF]

Asian Pac J Cancer Prev
Daungsupawong H, Wiwanitkit V.
europepmc   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

Lessons from 5 Years of Routine Whole-Genome Sequencing for Epidemiologic Surveillance of Shiga Toxin-Producing Escherichia coli, France, 2018-2022. [PDF]

Emerg Infect Dis
Jones G, Nodari CS, Fabre L, de Valk H, Noel H, Cointe A, Bonacorsi S, Weill FX, Le Strat Y.   +8 more
europepmc   +1 more source

Cattle Genomics: Aurochs Admixture in East Asia

Animal Research and One Health, EarlyView.
James A. Ward, David E. MacHugh
wiley   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Extensively Drug-Resistant Neisseria gonorrhoeae Strain, Canada. [PDF]

Emerg Infect Dis
Lefebvre B, Martin I, Thorington R, Gitelman J, Bui-Nguyen A, Fortin C, Fafard J.   +6 more
europepmc   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source