Results 211 to 220 of about 454,115 (308)

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

A novel missense single-nucleotide polymorphism (c.149G>A) in the bovine <i>leptin</i> gene and its association with growth traits in Madura cattle. [PDF]

Vet World
Kuswati K, Novianti I, Prafitri R, Septian WA, Putri RF, Nugraha CD, Furqon A.   +6 more
europepmc   +1 more source

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang, M. A. Magateshvaren Saras, K. Conn, E. Greaves, F. Reed, S. Tyagi, H. Munguba, C. J. Foldi   +7 more
wiley   +1 more source

Mendelian randomization study: The association between pain, analgesics, and frailty. [PDF]

Medicine (Baltimore)
Wu Z.
europepmc   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Early diagnostic value of novel biomarkers for breast cancer therapy‐related cardiac dysfunction

ESC Heart Failure, EarlyView.
Our meta‐analysis revealed significant post‐treatment increases in GDF‐15, CRP, MPO, and PLGF levels (Gal‐3 unchanged) among breast cancer patients. Only elevated MPO levels were significantly associated with an increased risk of cancer therapy‐related cardiac dysfunction (CTRCD).
Zhengwei Wang, Yujuan Wu, Jingyi He, Diansa Gao, Zhong Zuo   +4 more
wiley   +1 more source

Mean and variance heterogeneity loci impact kernel compositional traits in maize. [PDF]

Plant Genome
Ismail YMA, Mujjabi C, Olatoye MO, Gray S, Lipka AE, Bohn MO.   +5 more
europepmc   +1 more source

Integrated trajectories of systolic and diastolic function differentially associate with risk for heart failure with preserved and reduced ejection fraction and proteomic profiles

European Journal of Heart Failure, EarlyView.
Graphical overview of derivation and testing of multiparametric trajectories of cardiac function. This study identified six trajectories of LV systolic and diastolic function from mid‐ to late‐life. Predicted trajectory from single echocardiogram identified four trajectories at differential risk for HFpEF and HFrEF.
Anne Marie Reimer Jensen, James C. Ross, Victoria Arthur, Michael E. Hall, Kunihiro Matsushita, Brandon Lennep, Pamela L. Lutsey, Tor Biering‐Sørensen, Amil M. Shah   +8 more
wiley   +1 more source

Link between the ESR2 (rs3020449) polymorphism and breast cancer risk in Bangladeshi women. [PDF]

Sci Rep
Shayla TA, Arthi SR, Ivy SC, Islam MS, Shahriar M.   +4 more
europepmc   +1 more source

DNA-based prediction of external ear morphology in the Chinese population: an exploratory study. [PDF]

PeerJ
Wang X, Zhao Z, Wu J, Li Y, Yang Y, Liu B, Zhou C, Wang C, Chen X, Song F.   +9 more
europepmc   +1 more source