Results 61 to 70 of about 1,178,111 (366)

Creation and maintenance of variation in allorecognition loci

Frontiers in Immunology, 2011
Allorecognition is the ability of an organism to differentiate self or close relatives from unrelated individuals. Effective allorecognition systems are critical to the survival of organisms; they prevent inbreeding, protect against pathogens, and ...
Marie Louise Nydam, Tony eDe Tomaso
doaj   +1 more source

Genetic variability in exon 9 of PEPCK-M gene in different strains of chickens using PCR-RFLP method [PDF]

مجله بیوتکنولوژی کشاورزی, 2015
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the first step of the gluconeogenesis cycle. There are two isozymes forms of this enzyme, cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) and mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-
Zohreh Yousefi, Qodrat Rahimi Miyanaji, Zarbakht Ansari   +2 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

ζ-Glycine: insight into the mechanism of a polymorphic phase transition

IUCrJ, 2017
Glycine is the simplest and most polymorphic amino acid, with five phases having been structurally characterized at atmospheric or high pressure. A sixth form, the elusive ζ phase, was discovered over a decade ago as a short-lived intermediate which ...
Craig L. Bull, Giles Flowitt-Hill, Stefano de Gironcoli, Emine Küçükbenli, Simon Parsons, Cong Huy Pham, Helen Y. Playford, Matthew G. Tucker   +7 more
doaj   +1 more source

The CHRNA5 polymorphism (rs16969968) and its association with waterpipe smoking addiction among Jordanians

Arab Journal of Basic and Applied Sciences, 2020
Waterpipe smoking is a form of tobacco use that causes nicotine/tobacco dependence and has become a global health problem. In this study, the association of rs16969968 SNP in the CHRNA5 gene with waterpipe dependence was investigated.
Thaka’a K. Al-Omoush, Karem H. Alzoubi, Omar F. Khabour, Fawzi M. Alsheyab, Ahmed Abu-siniyeh, Nour A. Al-Sawalha, Fadia A. Mayyas, Caroline O. Cobb, Thomas Eissenberg   +8 more
doaj   +1 more source

Exon 2 of BMP15 gene polymorphism in Jabal Barez Red Goat [PDF]

مجله بیوتکنولوژی کشاورزی, 2010
Bone morphogenetic protein 15 (BMP15) is member of the transforming growth factor-beta superfamily that has crucial roles in fecundity of goat and sheep. Previous investigations confirmed that the fecundity mutations of sheep presented in goat. Different
Roohollah Alinaghizadeh, Mohammadreza Mohammadabadi, sonya zakizadeh   +2 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Calcium Carbonate Precipitation for CO2 Storage and Utilization: A Review of the Carbonate Crystallization and Polymorphism

Frontiers in Energy Research, 2017
The transformation of CO2 into a precipitated mineral carbonate through an ex situ mineral carbonation route is considered a promising option for CO2 capture and storage (CCS) since (i) the captured CO2 can be stored permanently, and (ii) industrial ...
Ribooga Chang, Semin Kim, Seungin Lee, Soyoung Choi, Minhee Kim, Youngjune Park   +5 more
semanticscholar   +1 more source

Influence of interleukin-10 gene polymorphism on the course of cystic fibrosis in children

Zdorovʹe Rebenka, 2018
Background. Cystic fibrosis (CF) features depend on a number of gene modifiers. Interleukin-10 (IL-10) gene is a one of these gene modifiers. The purpose was to improve medical care for patients with CF by clarifying the pathogenetic role of the IL-10 ...
N.M. Drobova
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source