Results 71 to 80 of about 727,358 (304)
Development of Sybr Green I-Based Melting Curve Method for HER2I655V Polymorphism Detection in Breast Cancer [PDF]
, 2016 Background: Currently available molecular method to detect HER2I655V polymorphism such as PCR-RFLP is hampered by the costly experimental method, and post-PCR treatment requirement that makes this technique is not meeting for high-throughput analysis ...
Budiarto, B. R. (Bugi) +2 more
core +3 more sources
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
ζ-Glycine: insight into the mechanism of a polymorphic phase transition
IUCrJ, 2017 Glycine is the simplest and most polymorphic amino acid, with five phases having been structurally characterized at atmospheric or high pressure. A sixth form, the elusive ζ phase, was discovered over a decade ago as a short-lived intermediate which ...
Craig L. Bull +7 more
doaj +1 more source
Arab Journal of Basic and Applied Sciences, 2020 Waterpipe smoking is a form of tobacco use that causes nicotine/tobacco dependence and has become a global health problem. In this study, the association of rs16969968 SNP in the CHRNA5 gene with waterpipe dependence was investigated.
Thaka’a K. Al-Omoush +8 more
doaj +1 more source
Exon 2 of BMP15 gene polymorphism in Jabal Barez Red Goat [PDF]
مجله بیوتکنولوژی کشاورزی, 2010 Bone morphogenetic protein 15 (BMP15) is member of the transforming growth factor-beta superfamily that has crucial roles in fecundity of goat and sheep. Previous investigations confirmed that the fecundity mutations of sheep presented in goat. Different
Roohollah Alinaghizadeh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Influence of interleukin-10 gene polymorphism on the course of cystic fibrosis in children
Zdorovʹe Rebenka, 2018 Background. Cystic fibrosis (CF) features depend on a number of gene modifiers. Interleukin-10 (IL-10) gene is a one of these gene modifiers. The purpose was to improve medical care for patients with CF by clarifying the pathogenetic role of the IL-10 ...
N.M. Drobova
doaj +1 more source
Generating Code with Polymorphic let: A Ballad of Value Restriction, Copying and Sharing [PDF]
EPTCS 241, 2017, pp. 1-22, 2017 Getting polymorphism and effects such as mutation to live together in the same language is a tale worth telling, under the recurring refrain of copying vs. sharing. We add new stanzas to the tale, about the ordeal to generate code with polymorphism and effects, and be sure it type-checks.
arxiv +1 more source
A polymorphism at IGF1 locus is associated with anemia [PDF]
, 2017 In vitro and in vivo studies suggest that IGF-1 has a role in erythropoiesis. There is evidence that the rs35767 C/T polymorphism near IGF1 is associated with plasma IGF-1 levels.
Andreozzi F +5 more
core +1 more source
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source