Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]
, 2014 Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag +62 more
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Absence of Association between CCR5 rs333 Polymorphism and Childhood Acute Lymphoblastic Leukemia
Advances in Hematology, 2014 Acute lymphoblastic leukemia (ALL) is a malignant disorder that originates from one single hematopoietic precursor committed to B- or T-cell lineage. Ordinarily, these cells express CCR5 chemokine receptor, which directs the immune response to a cellular
Carlos Eduardo Coral de Oliveira +7 more
doaj +1 more source
Frontiers in Genetics, 2014 We evaluated the relevance of the BovineHD Illumina SNP chip with respect to genes involved in epigenetic processes. Genotypes for 729,068 SNP on two tropical cattle breeds of Australia were used: Brahman (n = 2,112) and Tropical Composite (n = 2,550 ...
Laercio R Porto-Neto +4 more
doaj +1 more source
A universal method for automated gene mapping [PDF]
, 2005 Small insertions or deletions (InDels) constitute a ubiquituous class of sequence polymorphisms found in eukaryotic genomes. Here, we present an automated high-throughput genotyping method that relies on the detection of fragment-length polymorphisms ...
Basler, Konrad +6 more
core +2 more sources
Proceedings of the 54th Annual ACM SIGACT Symposium on Theory of Computing, 2022 For a function $g\colon\{0,1\}^m\to\{0,1\}$, a function $f\colon \{0,1\}^n\to\{0,1\}$ is called a $g$-polymorphism if their actions commute: $f(g(\mathsf{row}_1(Z)),\ldots,g(\mathsf{row}_n(Z))) = g(f(\mathsf{col}_1(Z)),\ldots,f(\mathsf{col}_m(Z)))$ for all $Z\in\{0,1\}^{n\times m}$.
Chase, Gilad +4 more
openaire +2 more sources
Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
Analytical Cellular Pathology, 2015 Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological ...
Marina Okuyama Kishima +6 more
doaj +1 more source
No association of CTLA-4 polymorphisms with susceptibility to Behcet disease [PDF]
, 2009 Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-
Du, L. +4 more
core +2 more sources
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]
, 2017 BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel +8 more
core +1 more source
Jornal de Pediatria, 2008 OBJETIVO: Verificar, em uma amostra de pacientes com asma atópica persistente leve, moderada e grave, a associação entre os polimorfismos dos genes fator de crescimento transformante-beta1 (TGF-beta1) (C-509T e T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R
Isabel C. J. de Faria +4 more
doaj +1 more source
Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]
, 2017 In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela +4 more
core +1 more source