Results 1 to 10 of about 62,432 (254)
Frontiers in Pharmacology, 2023 Objective: To investigate the clinical efficacy and toxicity of nebulized polymyxin monotherapy and combined intravenous and nebulized polymyxin for the treatment of VAP caused by CR-GNB.
Zhenping Wu +5 more
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Microbiology Spectrum, 2022 Carbapenem-resistant Gram-negative bacteria (CRGNB)-related health care-associated ventriculitis and meningitis (HCAVM) is dangerous. We aimed to report the antimicrobial resistance of the pathogens, treatment, and outcome.
Yi Ye +3 more
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Frontiers in Microbiology, 2023 IntroductionMatrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) is a powerful analytical technique that has been applied to a wide variety of applications ranging from proteomics to clinical diagnostics.
Wenhao Tang +3 more
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Clinical Microbiology Reviews, 2008 SUMMARY The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. Once discarded due to concerns regarding nephrotoxicity and neurotoxicity, polymyxins now hold an important role in the antibiotic armamentarium.
David, Landman +3 more
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Structures of Polymyxin B2 and Polymyxin E1 [PDF]
Nature, 1964 IN a previous communication1, from the analysis of a partial acid hydrolysate, the structure of polymyxin E1 was shown to be limited to two alternatives, the so-called 7 α and 8γ formulae. By applying the enzyme method of hydrolysis as devised by Suzuki et al. in their determinations of the structures of polymyxin B1 (ref. 2) and colistin A (ref.
S, WILKINSON, L A, LOWE
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Antibiotics, 2021 Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of mcr and blaNDM in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments ...
Dongyue Lv +11 more
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SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes [PDF]
, 2017 SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood.
Gary C. Port +4 more
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Frontiers in Microbiology, 2020 Currently, Gram-negative bacteria have developed multidrug and broad-spectrum drug resistance, and the numbers of species and strains carrying mcr or blaNDM genes are increasing.
Rong Fan +9 more
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mSphere, 2023 Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters for the delivery of cargo such as virulence and antibiotic resistance factors.
Maytham Hussein +9 more
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Progress in the study of polymyxin resistance and its mechanism
Shanghai yufang yixue, 2022 Drug-resistant bacteria have become a serious threat to human health. Polymyxin has shown strong bactericidal activity to some Gram-negative and Gram-positive bacteria that are resistant to antibiotics， and has become a last-resort treatment option ...
CAI Jia’an, JIANG Lufang, JIANG Qingwu
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