Results 101 to 110 of about 7,789 (207)
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo +6 more
wiley +1 more source
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri +11 more
wiley +1 more source
Physiologically Based Pharmacokinetic Modeling of Inhaled Polymyxin B: From Rabbit Optimization to Human Predictions [PDF]
Ramya Mahadevan +10 more
openalex +1 more source
Food package bulging, a prevalent spoilage issue in dairy products, beverages, and condiments, is predominantly attributed to gas‐producing spoilage bacteria. These contaminants originate from multiple pathways: raw material contamination, processing cross‐contamination, packaging material leaching, airborne microbial ingress, and inadequate control of
Xiao Liu +5 more
wiley +1 more source
ABSTRACT Background and Aims Infectious diseases in hospitals pose a significant threat, with some linked to contaminated food. Food safety is a critical issue for hospital patients, particularly those with weakened immune systems. This study aimed to conduct the first comprehensive microbial evaluation of hospital catering across 12 teaching hospitals
Mojtaba Raeisi +6 more
wiley +1 more source
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
Exploring Supramolecular Modulation of Polymyxin-Lipopolysaccharide Interactions
Nicoló Paracini +6 more
openalex +2 more sources
This One Health review maps the global prevalence of mcr‐mediated colistin resistance in Escherichia coli across human, animal, food, and environmental sectors. By tracking datasets across diverse geographic regions, the study highlights critical resistance hotspots, emphasizing the urgent need for integrated cross‐sectoral surveillance to limit global
Ferdous‐Ul‐Haque Joy +3 more
wiley +1 more source
POLYMYXIN P, NEW ANTIBIOTICS OF POLYMYXIN GROUP
Y, Kimura +4 more
openaire +3 more sources
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf +7 more
wiley +1 more source

