Results 81 to 90 of about 43,976 (255)

Images of LLC-PK1 cells incubated with Lissamine rhodamine-polymyxin B (LRhod-polymyxin B).

, 2016
Control cells incubated in physiological media (A), cells exposed to 75 μM LRhod-polymyxin B for 4 hours (B), cells exposed to 75 μM LRhod-PMB for 8 hours (C), and cells exposed to 75 μM LRhod-polymyxin B for 24 hours (D).
Edson Andrade Pessoa (2993853), Luciana Barros de Moura Neiva (2993850), Maria de Fátima Fernandes Vattimo (2993844), Cassiane Dezoti da Fonseca (2993841), Fernanda Teixeira Borges (2993838), Mirian Watanabe (2993847)   +5 more
core   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Effectiveness and safety of polymyxin B for the treatment of infections caused by extensively drug-resistant Gram-negative bacteria in Thailand

, 2018
Thundon Ngamprasertchai,1 Adhiratha Boonyasiri,2 Lantharita Charoenpong,3 Sireethorn Nimitvilai,4 Narisorn Lorchirachoonkul,5 Luksame Wattanamongkonsil,2 Visanu Thamlikitkul6 1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine ...
Lorchirachoonkul N, Charoenpong L, Ngamprasertchai T, Boonyasiri A, Wattanamongkonsil L, Thamlikitkul V, Nimitvilai S   +6 more
core  

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Clinical outcomes of lateral ear canal resection performed in routine clinical practice for chronic otitis externa in dogs: a retrospective descriptive study of 58 ears (2016‐2025)

Journal of Small Animal Practice, EarlyView.
Objectives To retrospectively evaluate the long‐term clinical outcomes of lateral ear canal resection performed as part of routine clinical practice for chronic otitis externa in dogs, and to re‐evaluate the practical utility of lateral ear canal resection from the perspective of contemporary treatment goals emphasising long‐term maintenance of a ...
K. Kiriki, A. Yabuzoe, K. Iyori
wiley   +1 more source

Polymyxin B vs colistin: The comparison of neurotoxic and nephrotoxic effects of the two polymyxins

Journal of Global Antimicrobial Resistance
AIM: To compare polymyxin B with colistimethate sodium (CMS) regarding neurotoxicity, nephrotoxicity, and 30-day mortality in patients with multi-drug resistant (MDR) gram-negative.
Pınar Aysert Yıldız, Ozge Ozgen Top, Ahmet Furkan Senturk, Sait Kanık, H. Selcuk Ozger, Murat Dizbay   +5 more
doaj   +1 more source

Polymyxin B-related neurotoxicity: a brief case report

, 2023
Polymyxin B and colistin are considered the last therapeutic option to treat infections caused by highly drug-resistant bacteria. However, their administration may lead to various adverse effects such as nephrotoxicity, neurotoxicity, and allergic ...
HALAÇLI, BURÇİN, Topeli, Arzu, Demirkan, Kutay, Bayraktar, Izgi   +3 more
core   +1 more source

Ocular Pharmacokinetics of Topical Chloramphenicol in Dogs: Effects of Concentration and Vehicle Formulation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study compared tear film exposure and retention of four chloramphenicol ophthalmic formulations in dogs, evaluating the effects of drug concentration (0.2% to 5%) and vehicle type (solution vs. ointment). Eight healthy dogs were enrolled in a randomized paired‐eye crossover study consisting of two sessions with a 7‐day washout.
Bar Fruchter, Oren Pe'er, Shir Gonen, Lionel Sebbag   +3 more
wiley   +1 more source

Treatment outcomes of patients with acinetobacter infection : comparison between polymyxin versus non polymyxin based therapy [PDF]

, 2019
Background: The growing resistance of Acinetobacter to almost all commercially available antibiotics is of major concern. Limited therapeutic options are currently available.
Jeeawoody, Aakil
core  

Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

, 2018
Polymyxins are a last line of defense against multidrug-resistant Gramnegative pathogens. Recent pharmacological data show that intravenous polymyxins can cause nephrotoxicity in up to 60% of patients, and the plasma concentrations of polymyxins achieved
Nation, Roger L., Sivanesan, Sivashangarie, Mohammad A. K. Azad, Roger L. Nation, Philip E. Thompson, Tony Velkov, Chen, Ke, Sivashangarie Sivanesan, Roberts, Kade D., Velkov, Tony, Jiping Wang, Jian Li, Wang, Jiping, Azad, Mohammad A. K., Kade D. Roberts, Ke Chen, Thompson, Philip E., Li, Jian   +17 more
core   +1 more source