Results 61 to 70 of about 43,976 (255)

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

, 2012
The emergence of very multiresistant Gram-negative bacterial strains has reinstated polymyxins (polymyxin B, colistin), pentacationic lipopeptides, in the therapy, in spite of their nephrotoxicity. Extensive tubular reabsorption concentrates polymyxin in
Denamur, Sophie, Vaara, Timo, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M., Vaara, Martti   +4 more
core   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges

Microorganisms, 2020
Colistin has been extensively used since the middle of the last century in animals, particularly in swine, for the control of enteric infections. Colistin is presently considered the last line of defense against human infections caused by multidrug ...
Ferdinando F. Andrade, Daniela Silva, Acácio Rodrigues, Cidália Pina-Vaz   +3 more
doaj   +1 more source

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

, 2022
Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To elucidate
Tonta, M, Tonta, Mary, Rosenbluh, J, Li, J, Azad, MAK, Parkington, HC, Lam, Rachel, Velkov, Tony, Jiang, Xukai, Wang, J, Velkov, T, Moreau, Julie L. M., Combes, AN, Zhu, Y, Li, Jian, Zhu, Yan, Moreau, JLM, Lam, R, Coleman, Harold A., Jiang, X, Wickremasinghe, Hasini, Zhao, Jinxin, Zhao, J, Lu, J, Rosenbluh, Joseph, Formosa, LE, Wang, Jiping, Azad, Mohammad A. K., Combes, Alexander N., Parkington, Helena C., Wickremasinghe, H, Lu, Jing, Coleman, HA, Formosa, Luke E.   +33 more
core   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis

Brazilian Journal of Infectious Diseases, 2018
A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients.
Cely Saad Abboud, Gauri G. Rao, Ercilia E. Souza, Alexandre P. Zavascki, Carlos Kiffer   +4 more
doaj   +1 more source

Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin B-Resistant KPC-Producing Klebsiella pneumoniae

, 2016
Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing K. pneumoniae and suppress the emergence of resistance. We investigated the pharmacodynamics of polymyxin B, rifampin, and meropenem alone and as polymyxin B ...
Rao, Gauri G., Diep, John K., Russo, Thomas A., Sharma, Rajnikant, Covelli, Jenna, Bowers, Dana R., Jacobs, David M.   +6 more
core   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

The effect of polymyxin on plant roots [PDF]

, 1955
Root growth of young seedlings of barley and other species was substantially inhibited when placed in 5-10 p.p.m. solutions of the antibiotic, polymyxin B.
Norman, A. G.
core   +1 more source