Results 51 to 60 of about 7,789 (207)

Evaluation of the Clinical Systems for Polymyxin Susceptibility Testing of Clinical Gram-Negative Bacteria in China

Frontiers in Microbiology, 2021
ObjectivesThe performance of mainstream commercial antimicrobial susceptibility testing systems on polymyxins has not been well evaluated in China. In this study, three antimicrobial susceptibility testing systems were evaluated for polymyxin B and ...
Ying Zhu, Ying Zhu, Peiyao Jia, Peiyao Jia, Menglan Zhou, Jingjia Zhang, Ge Zhang, Wei Kang, Simeng Duan, Tong Wang, Yingchun Xu, Qiwen Yang   +11 more
doaj   +1 more source

Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection

Brazilian Journal of Infectious Diseases, 2019
Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed.
Qiqiang Liang, Man Huang, Zhijiang Xu
doaj   +1 more source

Co‐Infection of Brucella canis and Brucella melitensis in a Domestic Dog With Zoonotic Transmission to Human, China

Animal Research and One Health, EarlyView.
Source attribution figure for human and dogs Brucella canis infections. ABSTRACT We report a rare occurrence of genetic material from both Brucella canis and B. melitensis detected in a domesticated dog from Jiangsu Province, China. The detection was confirmed through serological assays, quantitative PCR (qPCR), metagenomic and genomic sequencing ...
Shengxin Ge, Jian Xu, Qingchun Shen, Jiabo Ding, Xiaowen Yang   +4 more
wiley   +1 more source

Sphingolipid-mediated vesiculation in multidrug-resistant Sphingobacterium detergens under polymyxin B stress

Applied and Environmental Microbiology
Among environmentally widespread Sphingobacterium species, the animal feces isolate Sphingobacterium detergens E70 exhibited multidrug antibiotic resistance despite carrying few annotated antibiotic resistance genes (ARGs), prompting investigation of non-
Jihyeon Min, Yewon Woo, Yerim Park, Woojun Park   +3 more
doaj   +1 more source

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Computational and Structural Biotechnology Journal, 2018
Polymyxins are amongst the most important antibiotics in modern medicine, in recent times their clinical utility has been overshadowed by nosocomial outbreaks of polymyxin resistant MDR Gram-negative ‘superbugs’.
Maytham Hussein, Mei-Ling Han, Yan Zhu, Elena K. Schneider-Futschik, Xiaohan Hu, Qi Tony Zhou, Yu-Wei Lin, Dovile Anderson, Darren J. Creek, Daniel Hoyer, Jian Li, Tony Velkov   +11 more
doaj   +1 more source

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, EarlyView.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

Frontiers in Microbiology, 2018
Due to limited new antibiotics, polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria, in particular carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Thien B. Tran, Thien B. Tran, Jiping Wang, Jiping Wang, Yohei Doi, Tony Velkov, Tony Velkov, Phillip J. Bergen, Phillip J. Bergen, Jian Li   +9 more
doaj   +1 more source