Results 21 to 30 of about 62,432 (254)

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]

, 2016
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe, Forgione, Mariantonietta, Forneris, Federico, Lucidi, Alessia, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Mehdipour, Parinaz, Pilotto, Simona, Rotili, Dante, Speranzini, Valentina, Velankar, Sameer   +11 more
core   +2 more sources

Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect

Toxins, 2013
Endotoxin is a potent mediator of a broad range of patho-physiological effects in humans. It is present in all Gram negative (GN) bacteria. It would be expected that anti-endotoxin therapies, whether antibody based or not, would have an important ...
James C. Hurley
doaj   +1 more source

Rapid Detection of Polymyxin-Resistant Enterobacteriaceae from Blood Cultures. [PDF]

, 2016
Enterobacterial strains resistant to polymyxins are being increasingly reported worldwide. The conventional methods for detection of colistin-resistant isolates such as broth microdilution remain time-consuming (24 to 48 h), and methods such as disc ...
Dubois, V., Jayol, A., Nordmann, P., Poirel, L.   +3 more
core   +2 more sources

ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSR [PDF]

, 2011
The bacterial envelope is the interface with the surrounding environment and is consequently subjected to a barrage of noxious agents including a range of compounds with antimicrobial activity.
Andrea Hall, Appia-Ayme, Bader, Buelow, Cherepanov, Corinne Appia-Ayme, Danese, Datsenko, Delaney, Demeler, DiGiuseppe, Elaine Patrick, Fardini, Fleischer, Gary Rowley, Gemski, Graham, Graham, Hagenmaier, Hoiseth, Houry, Huang, Isaac, Kwon, Leonhartsberger, Merdanovic, Noll, Quan, Raffa, Raivio, Raivio, Rowley, Shiny Rajadurai, Tedin, Thede, Thomas A. Clarke, Uzzau, Zhao, Zhou   +38 more
core   +1 more source

Chronicle of a Soil Bacterium: Paenibacillus polymyxa E681 as a Tiny Guardian of Plant and Human Health

Frontiers in Microbiology, 2019
The Gram-positive rhizosphere bacterium Paenibacillus polymyxa promotes plant growth and produces various antibiotics. Herein, we review research on this species over the past two and a half decades, and focus on the mechanisms of P. polymyxa strain E681,
Haeyoung Jeong, Haeyoung Jeong, Soo-Keun Choi, Soo-Keun Choi, Choong-Min Ryu, Choong-Min Ryu, Seung-Hwan Park, Seung-Hwan Park   +7 more
doaj   +1 more source

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

mSystems, 2019
Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported.
Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li   +10 more
doaj   +3 more sources

Global burden of colistin-resistant bacteria : mobilized colistin resistance genes study (1980-2018) [PDF]

, 2019
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat.
Elbediwi, Mohammed, Fang, Weihuan, Feng, Youjun, Li, Xiaoliang, Li, Yan, Pan, Hang, Paudyal, Narayan, Rajkovic, Andreja, Rankin, Shelley C., Xie, Shaohua, Yue, Min   +10 more
core   +1 more source

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]

, 2012
Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura, Parnham, Michael J.   +6 more
core   +1 more source

Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes

BMC Genomics, 2011
Background Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in ...
Molinaro Antonio, Clarke Chelsea, Di Lorenzo Flaviana, Loutet Slade A, Valvano Miguel A   +4 more
doaj   +1 more source