Acetate‐Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness
The Pta–AckA pathway is critical for Haemophilus influenzae energy generation, metabolic homeostasis, stress resistance, and intracellular colonization, highlighting its potential as a target for management of H. influenzae infections.
Marufa Nasreen +8 more
wiley +1 more source
Antibiotic Resistance and Biofilm Gene Distribution in Colistin‐Resistant Acinetobacter baumannii
Multicenter analysis of 144 clinical Acinetobacter baumannii isolates in Iran revealed high MDR/XDR rates and widespread biofilm formation (90.9%). Colistin resistance was linked to pmrAB overexpression, while blaPER‐1 was independently associated with strong biofilm production, highlighting chromosomal resistance mechanisms and biofilm as key drivers ...
Zainab Amer Hatem +7 more
wiley +1 more source
NMB‐mediated aPDT significantly inhibited MDR A. baumannii and enhanced the efficacy of tigecycline and colistin through synergistic or additive interactions. Increased ROS generation during aPDT and combination therapy may contribute to the observed antibacterial effects.
Barat Barati +4 more
wiley +1 more source
Cell membrane‐coated nanoparticles for dermatological diseases
Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley +1 more source
Guidelines for Essential Trauma Care: Second Edition (2026)
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock +41 more
wiley +1 more source
Safety Profiles of Polymyxins, Aminoglycosides, and Imipenem/Cilastatin/Relebactam (IMI/REL) in the Treatment of Gram-Negative Infections: A Literature Review. [PDF]
Collings H +6 more
europepmc +1 more source
Predicting Microbial Growth Dynamics in Commercial Cocoa‐Flavored Plant‐Based Milk Alternatives
ABSTRACT This study evaluated the growth of Bacillus cereus, Escherichia coli, and Salmonella Typhimurium in commercially available cocoa‐flavored plant‐based milk alternatives (PBMAs) under different temperatures and examined the influence of product composition on bacterial development.
Clara Mariana Gonçalves Lima +4 more
wiley +1 more source
A systematic literature review and (network) meta-analysis of the effectiveness of ceftolozane/tazobactam versus aminoglycosides/polymyxins and ceftazidime/avibactam for treating adult patients with multidrug-resistant <i>Pseudomonas aeruginosa</i> infections. [PDF]
Collings H +6 more
europepmc +1 more source
This study isolated and identified a novel lytic phage that infects Pseudomonas aeruginosa. Henu5 exhibited good physicochemical stability. Additionally, the phage‐resistant mutants showed fitness trade‐offs in growth, virulence and antibiotic susceptibility, along with in vivo fitness, which might direct future phage selection in clinical settings ...
Salwa E. Gomaa +7 more
wiley +1 more source
Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections with Polymyxins: A Review. [PDF]
Li X, Chong W, Mo J, Liu J.
europepmc +1 more source

