Results 111 to 120 of about 11,434 (195)

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, Volume 13, Issue 50, 7 September 2026.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

A novel major facilitator superfamily-type tripartite efflux system CprABC mediates resistance to polymyxins in Chryseobacterium sp. PL22-22A

Frontiers in Microbiology
BackgroundPolymyxin B (PMB) and polymyxin E (colistin, CST) are polymyxin antibiotics, which are considered last-line therapeutic options against multidrug-resistant Gram-negative bacteria in serious infections.
Lu Zhang, Lu Zhang, Miao Wang, Rui Qi, Rui Qi, Yilin Yang, Yilin Yang, Ya Liu, Ya Liu, Nianqing Ren, Nianqing Ren, Zihan Feng, Zihan Feng, Qihao Liu, Qihao Liu, Guangxiang Cao, Guangxiang Cao, Gongli Zong, Gongli Zong   +18 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Pharmacodynamics of Polymyxins and Their Combinations with Carbapenems against Multidrug-Resistant Klebsiella pneumoniae

, 2017
Emergence of antibiotic-resistant bacteria and dearth of new chemical agents in the antibiotics development pipeline present a major medical challenge. The Infectious Diseases Society of America (IDSA) launched the “Bad Bugs, No Drugs” campaign in 2004 ...
Zakuan Zainy Deris (3745259)
core   +1 more source

Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug‐Resistant Bacteria: Preliminary Antibiotic–Interaction Screening and Exploratory Molecular Docking

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri, Sarra Elmsehli, Assia kenich, Mabrouk Horchani, Hanen Najjaa, Naima Najah, Hasan Aljohi, Mohammad Nasser Alkhrayef, Roberta Ascrizzi, Guido Flamini, Ibrahim O. Alanazi, Mozaniel Santana de Oliveira   +11 more
wiley   +1 more source

Polyphenol‐Based Biomaterials for Antibacterial Infection Management: From Assembly Chemistry to Infection Site‐Specific Therapeutic Platforms

cMat, Volume 3, Issue 3, September 2026.
Polyphenol assembly chemistry provides a versatile basis for antibacterial biomaterials. Matching material format and function to the distinct barriers of wound, respiratory, intestinal, and implant‐associated infections is central to effective and translatable design. ABSTRACT Bacterial infections involving multidrug‐resistant pathogens and persistent
Wei Yang, Li Wan, Ming Wen, Haiyan He, Hongliang Tan   +4 more
wiley   +1 more source

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, Volume 2, Issue 3, Page 147-164, September 2026.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

Editorial: Women in pharmacology of infectious diseases: 2021

Frontiers in Pharmacology, 2022
Elena K. Schneider-Futschik, Isabel Spriet, Hong Zhou   +2 more
doaj   +1 more source

Isolation and Identification of Gas‐Producing Spoilage Bacteria in Wasabi Sauce and Effective Methods for Controlling Their Growth

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Food package bulging, a prevalent spoilage issue in dairy products, beverages, and condiments, is predominantly attributed to gas‐producing spoilage bacteria. These contaminants originate from multiple pathways: raw material contamination, processing cross‐contamination, packaging material leaching, airborne microbial ingress, and inadequate control of
Xiao Liu, Hong Li, Qin‐Guo Xu, Weiwei Wu, Qing‐Dian Han, Yun‐Guo Liu   +5 more
wiley   +1 more source

Assessment of Pathogen Contamination in Food at Teaching Hospitals in Mashhad, Iran: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Infectious diseases in hospitals pose a significant threat, with some linked to contaminated food. Food safety is a critical issue for hospital patients, particularly those with weakened immune systems. This study aimed to conduct the first comprehensive microbial evaluation of hospital catering across 12 teaching hospitals
Mojtaba Raeisi, Fateme Asadi Touranlou, Golshan Shakeri, Maliheh Doustinouri, Arefeh Erfani, Asma Afshari, Mohammad Hashemi   +6 more
wiley   +1 more source