Results 51 to 60 of about 3,773 (182)
Resurrecting the Activity of the RNA Subunit of Human RNase P
ChemBioChem, Volume 27, Issue 6, 27 March 2026.The catalytic RNA (H1 RNA) of the human nuclear tRNA processing enzyme RNase P has >105‐fold lower activity in the absence of its 11 protein cofactors than bacterial RNase P RNAs. By introducing mutations toward the bacterial consensus into its catalytic domain, a two and fivefold activity enhancement could be achieved by changes in the P4‐19/4 region ...
Dan Li +2 more
wiley +1 more source
Motorized DNAzymes Drive Enhanced Electrochemical Biosensing for Rapid Bacterial Detection
Small Methods, Volume 10, Issue 6, 24 March 2026.The micromotor DNAzyme analyzer (Motolyzer) enables sensitive electrochemical detection of Legionella pneumophila proteins in unprocessed samples with high specificity. Upon target recognition, DNAzymes actively release redox barcodes, which are detected on DNA‐functionalized electrodes.
Amir Ali Akhlaghi +9 more
wiley +1 more source
Algorithmic Self-Assembly of DNA: Theoretical Motivations and 2D Assembly Experiments [PDF]
, 2000 Biology makes things far smaller and more complex than anything produced by human engineering. The biotechnology revolution has for the first time given us the tools necessary to consider engineering on the molecular level.
Winfree, Erik
core
FLASH: ultra-fast protocol to identify RNA-protein interactions in cells
, 2019 Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different aspects of gene regulation.
Akhtar, A. +4 more
core +1 more source
NOTCH1 can initiate NF-κB activation via cytosolic interactions with components of the T cell Signalosome. [PDF]
, 2014 T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10, and MALT1, which is required for TCR ...
Abdul H Fauq +13 more
core +2 more sources
DNA replication in vivo by a temperature-sensitive polynucleotide ligase mutant of T4. [PDF]
Proceedings of the National Academy of Sciences, 1968 DNA replication in vivo as function of temperature sensitive polynucleotide ligase mutant Th, tsA80 in strand ...
J, Hosoda, E, Mathews
openaire +2 more sources
Nanozymes Integrated Biochips Toward Smart Detection System
Advanced Science, Volume 13, Issue 11, 23 February 2026.This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen +10 more
wiley +1 more source
Mechanisms of DNA damage, repair, and mutagenesis [PDF]
, 2017 Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the ...
Chatterjee, Nimrat, Walker, Graham C
core +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park +13 more
wiley +1 more source
Viroids: Survivors from the RNA World? [PDF]
, 2014 Because RNA can be a carrier of genetic information and a biocatalyst, there is a consensus that it emerged before DNA and proteins, which eventually assumed these roles and relegated RNA to intermediate functions.
Flores, Ricardo +3 more
core +1 more source