Results 41 to 50 of about 19,008 (171)

Development of 134 novel polynucleotide-repeat microsatellite markers in silver carp (Hypophthalmichthys molitrix)

open access: yes, 2013
In this study, we developed 134 novel polymorphic polynucleotide-repeat microsatellite markers for silver carp (Hypophthalmichthys molitrix) and characterized 40 loci for polymorphism and genetic diversity in a test population.
Tong, Jingou   +3 more
core   +1 more source

Reversible Photocontrol of mRNA Synthesis and Cleavage for mRNA Concentration Switching Inside Artificial Cells

open access: yesChemSystemsChem, Volume 8, Issue 5, September 2026.
Azobenzene‐modified hairpin DNA (AzoPinDNA) controls transcription and mRNA cleavage. While visible light (vis) allows transcription by T7 RNA polymerase, UV irradiation triggers AzoPinDNA to open and hybridize with mRNA, inducing site‐specific cleavage by RNase H and inhibiting transcription.
Daichi Iwata   +7 more
wiley   +1 more source

Correction to A Dual-Enzyme-Assisted Three-Dimensional DNA Walking Machine Using T4 Polynucleotide Kinase as Activators and Application in Polynucleotide Kinase Assays

open access: yes, 2018
Correction to A Dual-Enzyme-Assisted Three-Dimensional DNA Walking Machine Using T4 Polynucleotide Kinase as Activators and Application in Polynucleotide Kinase ...
Zihan Wang (3129810)   +6 more
core   +1 more source

DNA–Peptide Crosslinks Placed at Codon 249 of the p53 Tumor Suppressor Gene Induce G to A Transitions in Human Cells

open access: yesChemBioChem, Volume 27, Issue 16, 27 August 2026.
DNA‐peptide cross‐links (DpCs) are ubiquitous DNA lesions that form when cellular proteins become covalently trapped on DNA strands and are processed by proteases. DpCs are hypothesized to play a role in antitumor activity of chemotherapeutic drugs and to contribute to aging.
Priscilla Yawson   +4 more
wiley   +1 more source

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger   +18 more
wiley   +1 more source

Regulation of SCF Ubiquitin Ligases by Jab1/Csn5 and the Cop9 Signalosome [PDF]

open access: yes, 2006
SCF ubiquitin ligases regulate the ubiquitin-dependent proteolysis of a myriad of substrate proteins, including p27, Cyclin E, and IkBa. To further gain insight into SCF regulation and function, we purified SCF from mammalian cells and found the Cop9 ...
Cope, Gregory Allan
core   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng   +9 more
wiley   +1 more source

Method for creating polynucleotide and polypeptide sequences [PDF]

open access: yes, 2003
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under conditions to generate annealed polynucleotides comprising ...
Shao, Zhixin   +2 more
core  

A capsid-encoded PPxY-motif facilitates adenovirus entry. [PDF]

open access: yes, 2010
Viruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of nonenveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed after cell surface attachment and ...
Segura-Morales, Carolina   +28 more
core   +1 more source

Polynucleotide Immunogenic Agents.

open access: yes, 1996
Polynucleotide immunogenic agents capable of inducing an immune response towards the members of the epidermal growth factor receptors (EGFR) family are ...
AMICI, Augusto   +2 more
core   +1 more source

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