Results 41 to 50 of about 3,773 (182)

Repair of Alkylated Bacteriophage T4 Deoxyribonucleic Acid by a Mechanism Involving Polynucleotide Ligase [PDF]

Journal of Virology, 1971
Methyl methanesulfate-induced lesions in bacteriophage T4 are repaired primarily by a mechanism involving polynucleotide ligase. Apparently, other recombinational and ultraviolet repair functions aren't involved.
M W, Baldy, B, Strom, H, Bernstein
openaire   +2 more sources

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

The Journal of Pathology, Volume 269, Issue 2, Page 164-181, June 2026.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen, Satu Tiainen, Jouni Kujala, Linnea Muhonen, Ponnuswamy Mohanasundaram, Tuomas Tikkanen, Ina Pöhner, Tommi Patinen, Simone Adinolfi, Juha P Väyrynen, Päivi Auvinen, Arto Mannermaa, Petri Pölönen, Tuomas Rauramaa, Anna‐Liisa Levonen   +14 more
wiley   +1 more source

The 2'-5' RNA Ligase of Escherichia coli: Purification, Cloning, and Genomic Disruption [PDF]

, 1996
An RNA ligase previously detected in extracts of Escherichia coli is capable of joining Saccharomyces cerevisiae tRNA splicing intermediates in the absence of ATP to form a 2-5 phosphodiester linkage (Greer, C., Javor, B., and Abelson, J. (1983) Cell 33,
Abelson, John N., Arn, Eric A.
core  

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria [PDF]

, 2014
Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells1,2 and may be used for therapeutic purposes to knockdown genes implicated in disease3. Thus far, most synthetic siRNAs have been produced
Deighan, Padraig, Huang, Linfeng, Jin, Jingmin, Kiner, Evgeny, Lieberman, Judy, McReynolds, Larry   +5 more
core   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, Volume 13, Issue 26, 8 May 2026.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia Type 3 pathogenesis [PDF]

, 2015
DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates.
A Das, A Das, A Jilani, A Silva-Fernandes, A Silva-Fernandes, AE Zolner, AG Mason, Anabela Silva-Fernandes, Andreia Neves-Carvalho, Anirban Chakraborty, Arnulf H. Koeppen, Arpita Chatterjee, B Burnett, BG Burnett, BJ Winborn, BO Evert, Castel A Lopez, CE Pearson, Christopher E. Pearson, CJ Whitehouse, D Banerjee, E Suberbielle, EW Doss-Pepe, F Karimi-Busheri, F Li, F Saudou, G Wang, H Date, H Paulson, H Segal-Raz, H Takashima, HL Paulson, I Plo, I Schmitt, IA Klement, Istvan Boldogh, IV Kovtun, J Shen, JD Dignam, JH Santos, JL Parsons, JM Warrick, KW Caldecott, KW Caldecott, L Schols, L Wiederhold, L Zhou, M Ljungman, MC Costa, MC Moreira, ML Hegde, Muralidhar L. Hegde, O Aygun, O Soderberg, Partha S. Sarkar, Patricia Maciel, Pavana M. Hegde, PJ McKinnon, PR Cook, R Alpatov, Raj K. Pandita, S Ayala-Torres, S Dey, S Fredriksson, S Katyal, Saikat Saha, Santi M. Mandal, SM Mandal, T Schmidt, Tapas K. Hazra, Tej K. Pandita, Tetsuo Ashizawa, W Liu, W Zhang, Y Chai, Y Kawaguchi, Y Mao, Y Trottier, Yongping Liu   +78 more
core   +4 more sources

Generation of Cloned Sheep Lacking Galactose‐α1,3‐Galactose and N‐Glycolylneuraminic Acid Antigens

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Sarah J. Appleby, Lisanne M. Fermin, Zachariah L. McLean, Stephanie Delaney, Stefan Wagner, Cecilia Di Genova, Jingwei Wei, Fanli Meng, David N. Wells, Björn Oback   +9 more
wiley   +1 more source

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4 [PDF]

, 2016
Telomeres shorten with each cell division and can ultimately become substrates for non-homologous end-joining repair, leading to large-scale genomic rearrangements of the kind frequently observed in human cancers. We have characterised over 1400 telomere
Ashelford, Kevin E., Baird, Duncan M., Harvey, Adam, Hendrickson, Eric A., Liddiard, Kate, Ruis, Brian, Takasugi, Taylor   +6 more
core   +2 more sources

Preserving DNAzyme Stability and Activity in Stool Samples for Clinical Diagnostics

Chemistry–Methods, Volume 6, Issue 4, April 2026.
A RNA‐cleaving DNAzymes often lose activity in stool due to extensive nuclease‐mediated degradation. This work introduces a simple heparin‐based treatment that preserves DNAzyme integrity and catalytic function in this highly challenging matrix, enabling reliable pathogen‐responsive signaling in stool samples.
Soyeon Lee, Jimmy Gu, Bruno J. Salena, Yingfu Li   +3 more
wiley   +1 more source

cDNAs encoding the large subunit of human replication factor C [PDF]

, 1993
Replication factor C (RFC) is a multisubunit, DNA polymerase accessory protein required for the coordinated synthesis of both DNA strands during simian virus 40 DNA replication in vitro. Previous studies have shown that RFC is a DNA-dependent ATPase that
Bunz, F., Kobayashi, R., Stillman, B.
core