The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks
BioEssays, Volume 48, Issue 1, January 2026.Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley +1 more source
Journal of Basic Microbiology, Volume 66, Issue 1, January 2026.ABSTRACT Mycobacteriophage Mcgavigan could be a promising candidate for use as a preventative agent against infections with Mycobacterium avium subsp. paratuberculosis. Bioinformatic analysis of the Mcgavigan genome revealed the presence of an operon containing a “Bxb1‐like” repressor.
Natali Shafer +2 more
wiley +1 more source
Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]
, 2008 The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus +6 more
core +2 more sources
DNA repair in cancer: emerging targets for personalized therapy [PDF]
, 2014 Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel +2 more
core +3 more sources
HLA‐Knockout: Enabling Allele‐Specific Knockout of HLA Class I Genes for Immunogenic Engineering
HLA, Volume 107, Issue 1, January 2026.ABSTRACT The interaction between T‐cell receptors (TCRs) and antigenic peptides presented by HLA molecules is fundamental to adaptive immunity. However, the extreme polymorphism of HLA genes poses major challenges for transplantation, antigen discovery, immunotherapy and studies of allele‐specific function.
Connor Mattivi +4 more
wiley +1 more source
Mammalian Base Excision Repair: the Forgotten Archangel [PDF]
, 2017 Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously ...
Dianov, Grigory L., Hübscher, Ulrich
core
Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency [PDF]
, 2016 The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve ...
Blundell, TL +6 more
core +2 more sources
XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency [PDF]
, 2015 Background Nonhomologous end-joining (NHEJ) is the major DNA double-strand break (DSB) repair mechanism in human cells. The final rejoining step requires DNA ligase IV (LIG4) together with the partner proteins X-ray repair cross-complementing protein ...
Björkman, Andrea +15 more
core +1 more source
Ultraviolet selection pressure on the earliest organisms [PDF]
Effects of UV selection pressure on evolutionary development patterns of early ...
Sagan, C.
core +1 more source
Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations [PDF]
, 2010 Background Proteomics was recently used to reveal enzymes whose expression is associated with the production of the glycopeptide antibiotic balhimycin in Amycolatopsis balhimycina batch cultivations.
Giuseppe Gallo +7 more
core +2 more sources