Results 71 to 80 of about 3,900 (192)

Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme [PDF]

, 2007
Programmed RNA breakage is an emerging theme underlying cellular responses to stress, virus infection and defense against foreign species. In many cases, site-specific cleavage of the target RNA generates 2′,3′ cyclic phosphate and 5′-OH ends.
Keppetipola, Niroshika, Nandakumar, Jayakrishnan, Shuman, Stewart   +2 more
core   +3 more sources

Algorithmic Self-Assembly of DNA: Theoretical Motivations and 2D Assembly Experiments [PDF]

, 2000
Biology makes things far smaller and more complex than anything produced by human engineering. The biotechnology revolution has for the first time given us the tools necessary to consider engineering on the molecular level.
Winfree, Erik
core  

FLASH: ultra-fast protocol to identify RNA-protein interactions in cells

, 2019
Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different aspects of gene regulation.
Akhtar, A., Aktas, T., Backofen, R., Ilik, I., Maticzka, D.   +4 more
core   +1 more source

Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]

, 1999
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike, Ali-Osman, Francis, Antoun, Gamil, Buolamwini, John K., Keller, Charles W., Lo, Hui-Wen, Lopez-Berestein, Gabriel   +6 more
core   +1 more source

Two distinct polynucleotide ligases from rat liver [PDF]

FEBS Letters, 1975
Teraoka, Hirobumi, Shimoyachi, Mari, Tsukada, Kinji   +2 more
openaire   +2 more sources

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria [PDF]

, 2014
Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells1,2 and may be used for therapeutic purposes to knockdown genes implicated in disease3. Thus far, most synthetic siRNAs have been produced
Deighan, Padraig, Huang, Linfeng, Jin, Jingmin, Kiner, Evgeny, Lieberman, Judy, McReynolds, Larry   +5 more
core   +1 more source

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability [PDF]

, 2015
DNA double-strand breaks (DSBs) are a significant threat to the viability of a normal cell, since they can result in loss of genetic material if mitosis or replication is attempted in their presence.
Arana, Audebert, Bartek, Bartkova, Barton, Bell, Bentley, Bentley, Beucher, Bolderson, Bouwman, Brady, Bryant, Budman, Budman, Bunting, Callen, Ceccaldi, Cerbinskaite, Chan, Chapman, Chapman, Choudhury, Cornforth, Deckbar, Deckbar, Deckbar, Dion, Dohrn, Ensminger, Erkko, Falck, Fan, Farmer, Fernandez-Capetillo, Fox, Fradet-Turcotte, Garcia, Gaymes, Gerhold, Geuting, Ghezraoui, Goodarzi, Helmink, Hu, Huertas, Jacot, Jasin, Jeggo, Jeggo, Jiang, Johnson, Kakarougkas, Kakarougkas, Kakarougkas, Kastan, Kemp, Kuhne, Li, Liang, Lieber, Lobrich, Loeb, Loucas, Maacke, Markus Löbrich, Mateos-Gomez, Michailidou, Muvarak, Neubauer, Panier, Panier, Penny A. Jeggo, Plisiecka-Halasa, Povirk, Prakash, Qiao, Radhakrishnan, Rahman, Riballo, Richardson, Roth, Sallmyr, Sarbajna, Seeber, Shanbhag, Shibata, Shibata, Shibata, Simsek, Soni, Steinel, Stephan, Syeda, Symington, Takenaka, Tepsuporn, Tobin, Tobin, Uziel, Wang, Wang, Ward, Waters, Waters, Williams, Woodbine, Woodbine, Yun, Zelensky, Zimmermann   +110 more
core   +1 more source

Template-Directed Ligation of Tethered Mononucleotides by T4 DNA Ligase for Kinase Ribozyme Selection [PDF]

, 2010
Background: In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species.
A Doherty, A Jaschke, AV Cherepanov, B Cho, B Cho, B Seelig, C Ho, D Loakes, D Loakes, D Saran, D Saran, David G. Nickens, DH Burke, Donald H. Burke, E Biondi, E Curtis, GF Joyce, I Chen, IR Lehman, J Jarvius, J Rumbaugh, James T. Patterson, JR Lorsch, M Hanczyc, M Moore, M Nilsson, M Saikia, Maxim Antopolsky, Nirmala Bardiya, P Liu, P Vallone, R Rossi, RC Alexander, S Ball, S Rhee, S Rhee, U Landegren, V Sriskanda, V Sriskanda, W Chiuman, W Wang, X Chen, Y Li, Y Wang   +43 more
core   +4 more sources

Archaea ATP-Dependent RNA Ligase [PDF]

, 2022
RNA ligases play important roles in repairing and circularizing RNAs post-transcriptionally. In this study, we generated an allelic knockout of ATP-dependent RNA ligase (Rnl) in the hyperthermophilic archaeon Thermococcus kodakarensis to identify its ...
Duong My Nguyen, Kieu, Hirata, Akira, Ho, C. Kiong, Hori, Hiroyuki, Liu, Yancheng, Sugijanto, Milyadi, Takagi, Yuko   +6 more
core  

Ultraviolet selection pressure on the earliest organisms [PDF]

Effects of UV selection pressure on evolutionary development patterns of early ...
Sagan, C.
core   +1 more source