Mammalian Base Excision Repair: the Forgotten Archangel [PDF]
, 2017 Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously ...
Dianov, Grigory L., Hübscher, Ulrich
core
Efficient and specific gene knockdown by small interfering RNAs produced in bacteria [PDF]
, 2014 Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells1,2 and may be used for therapeutic purposes to knockdown genes implicated in disease3. Thus far, most synthetic siRNAs have been produced
Deighan, Padraig +5 more
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Algorithmic Self-Assembly of DNA: Theoretical Motivations and 2D Assembly Experiments [PDF]
, 2000 Biology makes things far smaller and more complex than anything produced by human engineering. The biotechnology revolution has for the first time given us the tools necessary to consider engineering on the molecular level.
Winfree, Erik
core
How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability [PDF]
, 2015 DNA double-strand breaks (DSBs) are a significant threat to the viability of a normal cell, since they can result in loss of genetic material if mitosis or replication is attempted in their presence.
Arana +110 more
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T4 RNA Ligase 2 truncated active site mutants: improved tools for RNA analysis [PDF]
, 2011 Background T4 RNA ligases 1 and 2 are useful tools for RNA analysis. Their use upstream of RNA analyses such as high-throughput RNA sequencing and microarrays has recently increased their importance.
Fuchs, Ryan T +4 more
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Two distinct polynucleotide ligases from rat liver [PDF]
FEBS Letters, 1975 Teraoka, Hirobumi +2 more
openaire +2 more sources
Ultraviolet selection pressure on the earliest organisms [PDF]
Effects of UV selection pressure on evolutionary development patterns of early ...
Sagan, C.
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Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme [PDF]
, 2007 Programmed RNA breakage is an emerging theme underlying cellular responses to stress, virus infection and defense against foreign species. In many cases, site-specific cleavage of the target RNA generates 2′,3′ cyclic phosphate and 5′-OH ends.
Keppetipola, Niroshika +2 more
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Unwrapping the role of WRAP53β in DNA damage response [PDF]
, 2016 WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the ...
Rassoolzadeh, Hanif
core +1 more source
Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency [PDF]
, 2016 The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve ...
Blundell, TL +6 more
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