Results 81 to 90 of about 44,321 (243)

Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

Computational and Structural Biotechnology Journal, 2020
The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the formation of 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite the limited knowledge
Juan C. Gonzalez-Rivera, Asuka A. Orr, Sean M. Engels, Joseph M. Jakubowski, Mark W. Sherman, Katherine N. O'Connor, Tomas Matteson, Brendan C. Woodcock, Lydia M. Contreras, Phanourios Tamamis   +9 more
doaj   +1 more source

Graphene‐Based Liquid Cell Designs for In Situ Liquid‐Phase Transmission Electron Microscopy: Recent Developments and Perspectives

Small Science, Volume 5, Issue 12, December 2025.
This review highlights the advances in graphene liquid cell designs for in situ liquid‐phase transmission electron microscopy, spanning veil‐type, well‐type, liquid‐flowing‐type, and mixing‐type configurations. These developments collectively enable real‐time visualization of diverse reactions in liquid environments at atomic resolution, thereby ...
Hyeonjong Ma, Hyeongseung Kim, Jiwoong Yang   +2 more
wiley   +1 more source

Identification of Polynucleotide Phosphorylase (PNPase) in Escherichia coli Involved in Persister Formation

bioRxiv, 2018
Despite the identification of many genes and pathways involved in the persistence phenomenon of bacteria, the mechanisms of persistence are not well understood.
Nan Wu, Yumeng Zhang, Shanshan Zhang, Youhua Yuan, Shuang Liu, P. Cui, Wen Zhang, Ying Zhang   +7 more
semanticscholar   +1 more source

Maturation of Polycistronic mRNAs by the Endoribonuclease RNase Y and Its Associated Y-Complex in Bacillus Subtilis [PDF]

, 2018
Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery, Aaron, Lalanne, Jean-Benoit, Li, Gene-Wei, Losick, Richard   +3 more
core   +1 more source

Genome-Wide Study of mRNA Degradation and Transcript Elongation in Escherichia coli [PDF]

, 2015
An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria.
Chen, Huiyi, Ge, Hao, Shiroguchi, Katsuyuki, Xie, Xiaoliang Sunney   +3 more
core   +2 more sources

Inductively Coupled Plasma Mass Spectrometry Performance for the Measurement of Key Serum Minerals: A Comparative Study With Standard Quantification Methods

Journal of Clinical Laboratory Analysis, Volume 39, Issue 2, January 2025.
Analysis of real‐world cross‐sectional study data revealed relative errors between the standard method and ICP‐MS for the different minerals tested. Additionally, several outliers were observed exclusively in the ICP‐MS results, likely due to hemolysis or other unidentified factors.
Kosuke Kojo, Tomoko Oguri, Takazo Tanaka, Atsushi Ikeda, Takuya Shimizu, Shunsuke Fujimoto, Ayumi Nakazono, Yoshiyuki Nagumo, Shuya Kandori, Hiromitsu Negoro, Hiroyuki Nishiyama   +10 more
wiley   +1 more source

Impact of PNPase on the transcriptome of Rhodobacter sphaeroides and its cooperation with RNase III and RNase E

BMC Genomics, 2021
Background The polynucleotide phosphorylase (PNPase) is conserved among both Gram-positive and Gram-negative bacteria. As a core part of the Escherichia coli degradosome, PNPase is involved in maintaining proper RNA levels within the bacterial cell.
Daniel-Timon Spanka, Carina Maria Reuscher, Gabriele Klug   +2 more
doaj   +1 more source

The structure of Rph, an exoribonuclease from Bacillus anthracis, at 1.7 angstrom resolution [PDF]

, 2008
Maturation of tRNA precursors into functional tRNA molecules requires trimming of the primary transcript at both the 5' and 3' ends. Cleavage of nucleotides from the 3' stem of tRNA precursors, releasing nucleotide diphosphates, is accomplished in ...
Blagova, Elena V., Fogg, Mark J., Levdikov, Vladimir M., Rawlings, Andrea E., Wilkinson, Anthony J., Wilson, Keith S.   +5 more
core   +2 more sources

Cardiovascular Disease Management and Prevention in Saudi Arabia: Strategies, Risk Factors, and Targeted Interventions

International Journal of Clinical Practice, Volume 2025, Issue 1, 2025.
Cardiovascular diseases (CVDs) remain the main cause of mortality and are generally among the leading causes of morbidity worldwide, thus placing an immense burden on health care. They include coronary artery disease, heart failure, hypertensive heart disease, and stroke. Among these, common risk factors include hypertension, high cholesterol, diabetes,
Aseel Awad Alsaidan, Majed Alamri
wiley   +1 more source

Polynucleotide Phosphorylase of Micrococcus lysodeikticus

Journal of Biological Chemistry, 1966
Natalie\ M. Thanassi, Maxine F. Singer
openaire   +2 more sources