Results 51 to 60 of about 21,167 (270)
Life, 2019 The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
doaj +1 more source
Bloch oscillations of a soliton in a molecular chain [PDF]
The European Physical Journal B, 55, 85-87 (2007), 2013 The paper presents results of numerical experiments simulating Bloch oscillations of solitons in a deformable molecular chain in a constant electric field. By the example of a homogeneous polynucleotide chain it is shown that the system under consideration can demonstrate complicated dynamical regimes when at the field intensities less than a certain ...
arxiv +1 more source
Solvation Effects on Hole Mobility in the Poly G/Poly C Duplex [PDF]
Russian Journal of Physical Chemistry A, 86, 832-836 (2012), 2013 Theoretical calculations of solvation contribution to hole energy in a polynucleotide chain give very low hole mobility values at zero temperature, \mu < 10^{-3} cm^2/(V s). We calculated hole mobility at physiological temperature for the Poly G/Poly C DNA duplex, which gave substantially larger mobility values.
arxiv +1 more source
Biochemistry and Biophysics Reports, 2020 The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher
S.V. Stovbun +5 more
doaj
Sequencing intractable DNA to close microbial genomes. [PDF]
PLoS ONE, 2012 Advancement in high throughput DNA sequencing technologies has supported a rapid proliferation of microbial genome sequencing projects, providing the genetic blueprint for in-depth studies.
Richard A Hurt +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
The Benzothiazine Core as a Novel Motif for DNA-Binding Small Molecules
Molecules, 2023 A new series of 4H-1,3-benzothiazine dyes were prepared and fully characterized in an aqueous medium. Benzothiazine salts were synthesized either through the classical synthetic pathway using Buchwald–Hartwig amination or through economical and ...
Milena Mlakić +10 more
doaj +1 more source
Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof [PDF]
, 2006 The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but whose sequences differ between the two strains, as genetic
Demaille, Jacques +3 more
core
Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source