Results 61 to 70 of about 11,317 (212)

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

Aging Cell, EarlyView.
Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega   +3 more
wiley   +1 more source

Derivatization of unprotected polynucleotides

Nucleic Acids Research, 1983
A simple and efficient method for attaching amines to the terminal 5'-phosphate of unprotected oligonucleotides or nucleic acids in aqueous solution is described. The method is applicable to low molecular-weight amines, polypeptides, or proteins. The terminal 5'-phosphate of an oligonucleotide or nucleic acid reacts with a water-soluble carbodiimide in
Barbara C.F. Chu, Leslie E. Orgel, Geoffrey M. Wahl   +2 more
openaire   +4 more sources

Adsorption of Nucleic Acid Bases, Ribose, and Phosphate by Some Clay Minerals

Life, 2015
Besides having a large capacity for taking up organic molecules, clay minerals can catalyze a variety of organic reactions. Derived from rock weathering, clay minerals would have been abundant in the early Earth. As such, they might be expected to play a
Hideo Hashizume
doaj   +1 more source

Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin–antitoxin systems

The FEBS Journal, EarlyView.
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon, Noëlla Germain‐Amiot, Charlotte Oriol, Astrid Rouillon, Yoann Augagneur, Stéphane Dréano, Irène Nicolas, Alexandre Chenal, Arnaud Bondon, Soizic Chevance, Marie‐Laure Pinel‐Marie   +10 more
wiley   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, EarlyView.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Synthesis, Cyclopolymerization and Cyclo-Copolymerization of 9-(2-Diallylaminoethyl)adenine and Its Hydrochloride Salt

Molecules, 2012
We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine.
Karyn Usher, Alaa Ezzeddine, Lara Abramian, Kamal H. Bouhadir, Nikolay Vladimirov   +4 more
doaj   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Complete Mitochondrial Genomes Provide Evidence of a Killer Whale Refugium Off the Coast of Japan During the Last Glacial Maximum

Journal of Biogeography, EarlyView.
ABSTRACT Aim During glacial periods, highly mobile species often shifted to warmer, ice‐free regions known as refugia, which frequently maintained higher genetic diversity than newly colonised areas after glacial retreat. We analyse complete mitogenome sequences from 11 killer whale samples in Nemuro Strait to test the hypothesis that waters around ...
Olga A. Filatova, Ivan D. Fedutin, Ekaterina A. Borisova, Ilya G. Meschersky, Marina V. Shitova, Erich Hoyt, Andrew D. Foote   +6 more
wiley   +1 more source

A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides

Scientia Pharmaceutica, 2019
Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20−200 n) and the same lengths routine poly(dNTP) and poly(NTP) species were tested for their impact on catalytic activities of β-like DNA polymerases
Sergey Stovbun, Kirill Ermakov, Alexander Bukhvostov, Alexander Vedenkin, Dmitry Kuznetsov   +4 more
doaj   +1 more source

Naphthalene diimide–amino acid conjugates as novel fluorimetric and CD probes for differentiation between ds-DNA and ds-RNA

Beilstein Journal of Organic Chemistry, 2020
Two novel unnatural amino acids, prepared by linking a dicationic purple-coloured and fluorescent naphthalene diimide (NDI) at core position to amino acid side chains of variable length, strongly interacted with ds-DNA/RNA by threading intercalation ...
Annike Weißenstein, Myroslav O. Vysotsky, Ivo Piantanida, Frank Würthner   +3 more
doaj   +1 more source