Results 61 to 70 of about 22,699 (249)
Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders [PDF]
, 2014 The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for
Olson, Eric S., van Rooij, Eva
core +1 more source
Chemistry – A European Journal, EarlyView.Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale +2 more
wiley +1 more source
The Benzothiazine Core as a Novel Motif for DNA-Binding Small Molecules
Molecules, 2023 A new series of 4H-1,3-benzothiazine dyes were prepared and fully characterized in an aqueous medium. Benzothiazine salts were synthesized either through the classical synthetic pathway using Buchwald–Hartwig amination or through economical and ...
Milena Mlakić +10 more
doaj +1 more source
Temperature dependence of Raman vibrational bandwidths in poly(rA) and rAMP [PDF]
, 1993 Isotropic and anisotropic spontaneous Raman spectra were obtained from solutions of poly(ra) and rAMP in buffer. The temperature dependence of these spectra was measured to elucidate the influence of macromolecular dynamics and solvent dynamics on the ...
Greve, J., Otto, C., Terpstra, P.A.
core +2 more sources
Evolved DNAzymes and Stable Activation Chemistry Enable High‐Efficiency DNA Ligation
Chemistry – A European Journal, EarlyView.In vitro selection of pre‐structured DNA libraries and chemical screening of alternative activation groups yielded trans‐acting DNAzymes with faster ligation rates and enhanced DNA substrate stability. The combination of C3S1 DNAzymes and phosphobenzimidazole‐activated DNA substrates provides improved DNA ligation performance, offering promise for ...
Connor Nurmi +3 more
wiley +1 more source
Sequencing intractable DNA to close microbial genomes. [PDF]
PLoS ONE, 2012 Advancement in high throughput DNA sequencing technologies has supported a rapid proliferation of microbial genome sequencing projects, providing the genetic blueprint for in-depth studies.
Richard A Hurt +4 more
doaj +1 more source
Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication
Chemistry – A European Journal, EarlyView.This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin +3 more
wiley +1 more source
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972 Morio Ikehara, Masao Hattori
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Method for creating polynucleotide and polypeptide sequences [PDF]
, 2003 The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under conditions to generate annealed polynucleotides comprising ...
Arnold, Frances +2 more
core +1 more source
Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation [PDF]
, 1997 Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts.
Duynhoven, John P.M. van +8 more
core +2 more sources