Results 81 to 90 of about 38,341 (274)

Light‐Responsive Mononucleotide Coacervates

Chemistry – A European Journal, EarlyView.
Light‐responsive mononucleotide coacervates undergo reversible phase transitions via azobenzene photoisomerization. Coacervates with high‐valency azobenzenes remain stable under UV light, while those with low‐valency azobenzenes dissolve, enabling nucleotide release. This minimal system highlights the potential role of light for exploring energy‐driven
Edison Rafael Jimenez Granda, Hedi Karoui, Xavier Brilland, Jean‐Christophe Baret, Nicolas Martin   +4 more
wiley   +1 more source

Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up

BMC Musculoskeletal Disorders, 2021
Background A first-year interim analysis of this two-year study suggested that intra-articular injections of highly purified, natural-origin polynucleotides and hyaluronic acid (HA) as a fixed combination (PNHA) might improve knee function and joint pain
Cesare Stagni, Martina Rocchi, Alessandro Mazzotta, Nicolandrea Del Piccolo, Nicola Rani, Marco Govoni, Leonardo Vivarelli, Francesca Veronesi, Milena Fini, Dante Dallari   +9 more
doaj   +1 more source

Colloquium: Physical approaches to DNA sequencing and detection [PDF]

, 2008
With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, a revolutionary sequencing method is needed for the cost-effective and ...
Di Ventra, Massimiliano, Zwolak, Michael
core   +2 more sources

Analytical Study of Lanolin as Potential Biomarker of Prehistoric Sheep‐Shearing Practice

Chemistry–Methods, EarlyView.
Lanolin, a complex wax found on sheep wool, accumulates on shearing tools, such as flint and obsidian blades, used since the Neolithic. This study explores lanolin's degradation patterns as a potential biomarker for prehistoric sheep‐shearing practices, employing micro‐Fourier transformed infrared spectroscopy, hyperspectral imaging, and gas ...
Claudia Adsuar Fuster, Francesco Caruso, Olivia Gómez‐Laserna, Martina Romani, Ramón J. Barrio, Josep Maria Vergès, Vincenza Forgia, Maite Maguregui, Asier Vallejo   +8 more
wiley   +1 more source

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides

Analytical Cellular Pathology, 2013
Interactions of cationic tetrakis (N, N′, N″, N‴- tetramethyltetra-3, 4-pyridinoporphyrazinatozinc (II) (Zn (tmtppa)) with synthetic polynucleotides, poly (G-C) and poly (A-T), and calf thymus DNA have been characterized in 7.5 mM phosphate buffer of pH ...
Hamid Dezhampanah, Soghra Fyzolahjani
doaj   +1 more source

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

Entropy, 2013
3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ...
Samanta Pino, Giovanna Costanzo, Alessandra Giorgi, Jiří Šponer, Judit E. Šponer, Ernesto Di Mauro   +5 more
doaj   +1 more source

DNA Renaturation at the Water-Phenol Interface [PDF]

, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
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core   +3 more sources

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections or tissue injuries. We show that the ability of a virus
Koichi Suzuki, Atsumi Mori, K. Ishii, J. Saito, D. Singer, D. Klinman, P. Krause, L. Kohn   +7 more
semanticscholar   +1 more source

Viral Evolution and Adaptation as a Multivariate Branching Process [PDF]

, 2011
In the present work we analyze the problem of adaptation and evolution of RNA virus populations, by defining the basic stochastic model as a multivariate branching process in close relation with the branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in
arxiv   +1 more source