Results 141 to 150 of about 22,479,757 (178)

Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway

Toxins, 2018
Polyphyllin VI, which is an active saponin, is mainly isolated from traditional medicinal plant Paris polyphylla, which causes liver damage in rats. In the present study, we aimed to explore the potential cytotoxicity of polyphyllin VI on the growth of ...
Longtai You, Wenping Wang, Yi Liu
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Anti-cancer effects of Polyphyllin I: An update in 5 years

Chemico-Biological Interactions, 2020
Chong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine. Polyphyllin I (PPI) is the main bioactive component in Paris polyphylla. Recent studies of PPI in various types of cancers have shown that PPI may exert a broad spectrum of
Ye, Tian, Guan-Yu, Gong, Liang-Liang, Ma, Zhuo-Qun, Wang, Dan, Song, Mei-Yun, Fang   +5 more
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Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC‐MS‐MS

Biomedical Chromatography, 2012
ABSTRACTFor the first time, a rapid and specific LC‐MS‐MS method has been developed for the analysis of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma. The method was applied to study the pharmacokinetics of Rhizoma Paridis extracts containing polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII. The
Xingbin, Yin, Changhai, Qu, Zhaoxia, Li, Yujing, Zhai, Sali, Cao, Longfei, Lin, Lijun, Feng, Lei, Yan, Jian, Ni   +8 more
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A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells

Bioorganic & Medicinal Chemistry Letters, 2016
Polyphyllin I (PPI) and formosanin C (FC) were regarded as effective and imperative components isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti-tumor effects on a variety of cancers. With the wide application of complex mixtures in clinics, synergistic interactions are of vital importance in phytomedicine.
Jing Liu, Shuli Man, Zhen Liu, Long Ma, Wenyuan Gao   +4 more
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Comparative transcriptome analysis reveals key genes for polyphyllin difference in five Paris species

Physiologia Plantarum, 2022
Abstract Paris species accumulate a large amount of steroidal saponins, which have numerous pharmacological activities and have become an essential component in many patented drugs. However, only two among all Paris species. Paris
Lixiu Hou, Furui Zhang, Xincheng Yuan, Song Li, Weijun Tian, Weirong Tian, Jiaru Li   +6 more
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Polyphyllin I in malignant tumors: molecular mechanisms and advances

Phytomedicine
Natural products derived from traditional Chinese medicine have become an important focus in anticancer drug discovery due to their favorable safety profiles and multi-target properties. Polyphyllin I (PPI), a major bioactive constituent of Rhizoma Paridis (Chong-lou), represents the key pharmacological basis for its traditional uses, including heat ...
Yiyan Zhai, Xiangli Yin, Zeyu Xue, Zijian Xu, Huiling Lei, Peiying Lu, Xiaodong Chen, Meiling Guo, Junyi Li, Muyassar Mamattohti, Xiaojing Zhao, Chunguo Wang, Jiarui Wu   +12 more
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Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells

Phytomedicine, 2015
Polyphyllin I (PPI), a bioactive phytochemical isolated from the rhizoma of Paris polyphyllin, exerts preclinical anticancer efficacy in various cancer models. However, the effects of PPI on regulatory human hepatocellular carcinoma (HCC) cell proliferation and its underlying mechanisms remain unknown.This study investigated the antiproliferation ...
Ya-Min Shi, Lei Yang, Ya-Di Geng, Chao Zhang, Ling-Yi Kong   +4 more
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New insights into endophytic fungi diversity and their potential correlation with polyphyllin levels of Paris polyphylla var. yunnanensis

Canadian Journal of Microbiology, 2023
Endophytes confer fitness advantages to host plants. However, the ecological communities of endophytic fungi in the different tissues (rhizomes, stems, and leaves) of Paris polyphylla and the relationship of their endophytic fungi with polyphyllin levels remain unclear.
Juan Lan, Ting Liu, Liyun Miao, Ting Pei, Zhe Gan, Aihua Lin, Hong Geng, Peng Zhang   +7 more
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Anticancer activity of polyphyllin I in nasopharyngeal carcinoma by modulation of lncRNA ROR and P53 signalling

Journal of Drug Targeting, 2019
Nasopharyngeal carcinoma (NPC) is the most common aggressive squamous cell carcinoma in head and neck cancers. Although advanced radiochemotherapy has been applied, the prognosis of NPC patients still remains poor due to the regional relapse and distant metastasis.
Feilong, Hong, Wenyue, Gu, Jin, Jiang, Xinge, Liu, Hao, Jiang   +4 more
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Two rhamnosyltransferases for de novo biosynthesis of polyphyllins in Nicotiana benthamiana

The Plant Journal
SUMMARYPolyphyllins, a prominent class of steroidal saponins in Paris species, owe their diverse bioactivities to their sugar unit configurations, though their glycosylation pathways remain poorly understood. Here, we identified and characterized two UDP‐rhamnosyltransferases, PpUGT73YD1 and PpUGT738A2, using heterologous expression systems.
Wei Song, Tong Li, Shan Yan, Mingyue Zhang, Xiaojing Ma, Liping Kang, Xin Hua, Zheyong Xue   +7 more
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