Results 151 to 160 of about 22,479,757 (178)

Influence of Nutritional Status on the Absorption of Polyphyllin I, an Anticancer Candidate from Paris polyphylla in Rats

European Journal of Drug Metabolism and Pharmacokinetics, 2018
Protein-calorie malnutrition (PCM) is one of the most suffered complications in cancer patients. Polyphyllin I (PPI), a saponin isolated from rhizome of Paris polyphylla, is a potential candidate in cancer therapy. In this study, the influence of nutritional status on the absorption of PPI in rats was explored after oral administration.PCM rats, namely
Feng-Ling Yu, Wei-Liang Gong, Fang-Jiang Xu, Jun-Wen Wu, Shailendra Shakya, He Zhu   +5 more
openaire   +2 more sources

Molecular Mechanisms of Polyphyllin I-Induced Apoptosis and Reversal of the Epithelial–Mesenchymal Transition in Human Osteosarcoma Cells

Journal of Ethnopharmacology, 2015
Osteosarcoma is a most common highly malignant bone tumor in children and adolescents. Polyphyllin I (PPI) is an ethanol extraction from Paris polyphylla Smith var.yunnanensis (Franch.) Hand.-Mazz, which belongs to antipyretic-detoxicate family and has been used as a natural medicine in the treatment of infectious disease and cancer in China for ...
Yongjun Wang, Dongfeng Zhao, Qi Shi
exaly   +3 more sources

Polyphyllin I Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment

Nutrition and Cancer
Cervical cancer (CC) is a common gynecological malignancy, and improving cisplatin sensitivity has become a hot topic in CC chemotherapy research. Polyphyllin I (PPI), a potent bioactive compound found in Rhizoma Paridis, known for its anticancer properties, remains underexplored in CC resistance.
Lu, Zhang, Wenzhi, Liu, Yu, Li, Yuanyuan, Fu, Chuanhua, Xu, Minmin, Yu   +5 more
openaire   +2 more sources

Polyphyllin I mitigates psoriasiform inflammation and prevents relapse by modulating CLEC7A and inhibiting pyroptosis

Phytomedicine
Psoriasis remains a significant global health concern, with a lack of effective treatments, thus driving the need for innovative therapeutic approaches. Polyphyllin I (PPI) has demonstrated potential in mitigating inflammation and controlling cellular growth, although the precise mechanisms underlying its effects and its full therapeutic capabilities ...
Xiangnan Zhou, Qilong Chen, Ziyin Chen, Biao Song, Jihong Li, Jingyuan Ning   +5 more
openaire   +2 more sources

Polyphyllin I in Malignant Tumors: Molecular Mechanisms and Recent Advances

BackgroundRhizoma Paridis (Chong-lou) is a widely used traditional Chinese medicine known for its effects in reducing swelling, relieving pain, and clearing heat and toxins. Modern pharmacological studies have confirmed that it possesses antibacterial, anti-inflammatory, analgesic, anticancer, and immunoregulatory properties.
Yiyan Zhai, Xiangli Yin, Zeyu Xue, Zijian Xu, Huiling Lei, Peiying Lu, Xiaodong Chen, Meiling Guo, Junyi Li, Muyassar Mamattohti, Xiaojing Zhao, Chunguo Wang, Jiarui Wu   +12 more
openaire   +1 more source

Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways

Toxicology Mechanisms and Methods, 2020
Aims: Polyphyllin I, a steroidal saponin in Rhizoma paridis, which possess broad application prospects in cancer prevention and treatment. The purpose of this study was to determine the potential cytotoxicity and mechanism of Polyphyllin I in HepG2 cells.Main methods: In this study, we used MTT to evaluate cell survival. Cell apoptosis rate, cell cycle
Yawen Zeng, Zhiqin Zhang, Wenping Wang, Longtai You, Xiaoxv Dong, Xingbin Yin, Changhai Qu, Jian Ni   +7 more
openaire   +2 more sources

Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression

Current Molecular Medicine
Background: Osteoarthritis (OA) is a chronic joint disease characterized by the degradation of articular cartilage. Polyphyllin I (PPI) has anti-inflammatory effects in many diseases. However, the mechanism of PPI in OA remains unclear. Methods: HC-a cells treated with IL-1β were identified by immunofluorescence staining and microscopic observation.
Feng, Liu, Bowen, Han, Deshun, Yang, Xiaopeng, Ji, Liangliang, Yan, Chaoyong, Han   +5 more
openaire   +2 more sources

[Effect and mechanism of polyphyllin I on human cervical cancer cell HeLa in vitro].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014
To study the effect and mechanism of polyphyllin I on human cervical cancer cell HeLa.The cell growth and proliferation effect of Polyphyllin I on HeLa cells were measured by MTT assay; Hoechst 33258 fluorescent staining was used to record changes in cell morphology and morphological changes in mitochondria of Polyphyllin I before and after treatment ...
Hui, Cheng, Jing-jing, Su, Hui-jie, Hou, Qing-lin, Li   +3 more
openaire   +1 more source

De Novo Biosynthesis of Polyphyllin V in Nicotiana benthamiana through Pathway Reconstruction and UDP-Sugar Engineering

ACS Synthetic Biology
Polyphyllin V (PPV) is a pharmaceutically valuable steroidal saponin with extremely low natural abundance, severely limiting its research and application. Here we established an efficient plant-based production platform for PPV in Nicotiana benthamiana through systematic optimization of glycosyltransferases and UDP-sugar metabolism.
Wei Song, Saba Shafi, Wenjing Zeng, Fengge Wang, Jiming Tian, Huiting Zhang, Shilong Liu, Thomas Efferth, Hongbo Zhang, Xin Hua, Zheyong Xue   +10 more
openaire   +2 more sources

Polyphyllin I enhances the anti-tumor efficacy of Palbociclib by reversing M2 macrophage polarization in lung cancer

Biochemical and Biophysical Research Communications
Lung cancer is a significant hazard to human health, with limited treatment options. Although CDK4/6 inhibitors like Palbociclib (Palb) have shown clinical promise, their effectiveness is often compromised by resistance. Our findings indicate that the Palb may promote M2-like macrophage polarization, which can facilitate tumor progression through ...
Yulan, Jiang, Lu, Wang, Yu, Chen, Ying, Li, Guanping, Chen, Yingyan, Lu, Cheng, Jiang, Kequn, Chai, Yifan, Wang   +8 more
openaire   +2 more sources