Results 91 to 100 of about 23,545 (244)

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui   +10 more
wiley   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source

Binucleation ramps up gene expression meeting the physiological demands of an organism

open access: yesPLoS Biology, 2022
In this issue of PLOS Biology, van Rijnberk and colleagues show how polyploidy, via binucleation, enables Caenorhabditis elegans intestinal cells to ramp up gene expression supplying the oocytes with the necessary lipids for optimal organismal growth and
Ari S. Dehn, Vicki P. Losick
doaj  

Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley   +1 more source

Genotype-specific responses to polyploidy induction in coriander using colchicine treatments

open access: yesDiscover Plants
Polyploidy plays a critical role in driving diversification and adaptation in many plant species, affecting physiological, developmental, and morphological traits. Here, we explore genotype-specific responses to colchicine-induced polyploidy in coriander
Zahra Zangishehei   +2 more
doaj   +1 more source

The Host Coral Bleaching Response Viewed Through the Lens of Multi‐Omics

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Coral bleaching is driven by multiple inputs, with heat stress and/or high irradiance being most important. The bleaching response is multifactorial with host animal species/strain and algal symbiont genotypes being critical features. Omics readout of heat stress responses includes gene expression, proteomics, metabolite, and SNP data with transcript ...
Debashish Bhattacharya   +4 more
wiley   +1 more source

Developing an understanding of American elderberry (Sambucus nigra subsp. canadensis (L.) Bolli) to support breeding efforts

open access: yesCrop Science, Volume 66, Issue 1, January/February 2026.
Abstract Elderberries (Sambucus spp.) have been valued as food and medicine around the world for millennia. Elderberry products are experiencing an increase in demand as ongoing research substantiates their putative health benefits. European elderberries (Sambucus nigra subsp. nigra) are an established industry in Europe and are often imported into the
Elizabeth Prenger   +2 more
wiley   +1 more source

Plant Traits as Potential Drivers of Timber Value in the Dipterocarpaceae

open access: yesEcology and Evolution, Volume 16, Issue 1, January 2026.
This study examines how plant traits and wood density influence timber market value in Southeast Asia's Dipterocarpaceae family. Using a phylogenetic approach, it finds that higher wood density is linked to greater timber prices, while conservation status does not correlate with market value.
Nazrin Malik   +2 more
wiley   +1 more source

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