Results 71 to 80 of about 22,407 (233)
Integrative Zoology, EarlyView.We have constructed the chromosome‐scale genome and investigated the evolutionary genomics of Schizopygopsis younghusbandi, a fish species native to the Yarlung Tsangpo River on the Tibetan Plateau. Our study indicated that this species diverged from other Schizothoracine fish approximately 4.2 million years ago, during the Neogene Tibetan uplift ...
Chaowei ZHOU +15 more
wiley +1 more source
Reconciling Event-Labeled Gene Trees with MUL-trees and Species Networks [PDF]
arXiv, 2018 Phylogenomics commonly aims to construct evolutionary trees from genomic sequence information. One way to approach this problem is to first estimate event-labeled gene trees (i.e., rooted trees whose non-leaf vertices are labeled by speciation or gene duplication events), and to then look for a species tree which can be reconciled with this tree ...
arxiv
Cell Proliferation, EarlyView.To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman +12 more
wiley +1 more source
Tumour Cell Size Control and Its Impact on Tumour Cell Function
Cell Proliferation, EarlyView.The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley +1 more source
Karyotype analysis in 19 families from the Qinghai–Tibetan Plateau and its evolution implications
Caryologia, 2022 The chromosome numbers and karyotypes of 79 species and accessions from 19 plant families growing on the Qinghai–Tibetan Plateau were investigated. For 31 species, we provided first insights into their chromosomal numbers and karyotypic characteristics ...
Ning Zhou
doaj
The FEBS Journal, EarlyView.A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara +9 more
wiley +1 more source
Production of autotetraploid plants by in vitro chromosome engineering in Allium hirtifolium
Horticultural Plant Journal, 2023 Persian shallot has been propagated vegetatively through daughter bulbs and has a narrow genetic base. In the present study, to create genetic diversity in terms of ploidy level, the effects of in vitro polyploidization were investigated on morphological,
Nasrin Farhadi +3 more
doaj
Synthetic Polyploidy in Grafted Crops
Frontiers in Plant Science, 2020 Synthetic polyploids have been extensively studied for breeding in the last decade. However, the use of such genotypes at the agronomical level is still limited.
Marta Ruiz +4 more
doaj +1 more source
Journal of Fish Biology, EarlyView.Abstract Routine observations of blood smears have repeatedly shown that triploid fish have a greater proportion of erythrocytes with nuclear segmentation (ENS) than diploids; however, there is as yet no understanding of why this is the case and whether it affects erythrocyte function.
John D. Clark +4 more
wiley +1 more source