Results 1 to 10 of about 1,561 (117)

Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis [PDF]

Molecular Metabolism
Objective: Metabolic-associated fatty liver disease (MAFLD) represents one of the most prevalent chronic liver conditions worldwide, but its precise pathogenesis remains unclear.
Canghai Guan, Xinlei Zou, Chengru Yang, Wujiang Shi, Jianjun Gao, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong   +8 more
doaj   +4 more sources

A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery

Advanced Science, 2023
Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake of extracellular miRNAs by recipient cells and their intracellular transport, however, remains elusive.
Jiachen Liu, Weili Li, Jianfeng Li, Eli Song, Hongwei Liang, Weiwei Rong, Xinli Jiang, Nuo Xu, Wei Wang, Shuang Qu, Shouyong Gu, Yujing Zhang, Chen‐ Yu Zhang, Ke Zen   +13 more
doaj   +2 more sources

Additional routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing, transcriptional profiling, and phenotypic studies. [PDF]

PLoS ONE, 2013
Daptomycin is an extensively used anti-staphylococcal agent due to the rise in methicillin-resistant Staphylococcus aureus, but the mechanism(s) of resistance is poorly understood.
Yang Song, Aileen Rubio, Radheshyam K Jayaswal, Jared A Silverman, Brian J Wilkinson   +4 more
doaj   +6 more sources

Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance [PDF]

Cell Reports
Summary: Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment.
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny Akers, Thien Nguyen, Eric Wong, Margot Martinez Moreno, Efrosini Kokkoli, Shobha Vasudevan, Sean E. Lawler, Wafik S. El-Deiry, Ziya Gokaslan, Clark C. Chen   +14 more
doaj   +2 more sources

cGAS/STING-Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B. [PDF]

FASEB J
Mechanism of HEXIM1 regulation of Type I Interferon. ABSTRACT Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi
Montano MM, Yeh IJ, Ketchart W.
europepmc   +2 more sources

SP1 and NFY Regulate the Expression of PNPT1, a Gene Encoding a Mitochondrial Protein Involved in Cancer. [PDF]

Int J Mol Sci, 2022
The Polyribonucleotide nucleotidyltransferase 1 gene (PNPT1) encodes polynucleotide phosphorylase (PNPase), a 30-50 exoribonuclease involved in mitochondrial RNA degradation and surveillance and RNA import into the mitochondrion.
Ventura I, Revert F, Revert-Ros F, Gómez-Tatay L, Prieto-Ruiz JA, Hernández-Andreu JM.   +5 more
europepmc   +3 more sources

Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy. [PDF]

Eur J Neurol
ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Haddad S, Record CJ, Self E, Skorupinska M, Rossor AM, Laura M, Ingle G, Manzur A, Muntoni F, Blake JC, Reilly MM.   +10 more
europepmc   +2 more sources

Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis [PDF]

npj Biofilms and Microbiomes
Peri-implantitis is a severe biofilm-associated infection affecting millions worldwide. This cross-sectional study aimed to identify taxonomic and functional biomarkers that reliably indicate peri-implantitis by utilizing paired data from full length 16S
Amruta A. Joshi, Szymon P. Szafrański, Matthias Steglich, Ines Yang, Taoran Qu, Paula Schaefer-Dreyer, Xing Xiao, Wiebke Behrens, Jasmin Grischke, Susanne Häussler, Meike Stiesch   +10 more
doaj   +2 more sources

Proteomic characterization and cytotoxic potential of proteins from Cuscuta (Cuscuta epithymum (L.) crude herbal product against MCF-7 human breast cancer cell line [PDF]

BMC Complementary Medicine and Therapies
Background The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals that exhibit ...
Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed   +6 more
doaj   +2 more sources

Mitochondrial RNA maturation. [PDF]

RNA Biol
\ua9 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The vast majority of oxygen-utilizing eukaryotes need to express their own mitochondrial genome, mtDNA, to survive.
Chrzanowska-Lightowlers ZM, Lightowlers RN.   +1 more
europepmc   +3 more sources