A novel exo-lytic and disaccharide-yielding glycosaminoglycan lyase from a marine-derived polysaccharide-degrading actinobacterium Microbacterium sp. strain WS15 [PDF]
Frontiers in MicrobiologyIntroductionGlycosaminoglycan (GAG) lyases play key roles in preparing oligosaccharides, treating human diseases, and learning relationships between complex structures and various functions of carbohydrates.
Peng Li +8 more
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Characterization of Alginate Utilization Strategy in a Novel Marine Bacteroidetes: Insights from Roseihalotalea indica gen. nov. sp. nov. TK19036T [PDF]
Marine DrugsAlginate, a major polysaccharide in brown algae, is vital for the carbon cycling of the ocean ecosystem and holds promise for biotechnological applications. Marine Bacteroidetes, known for the ability to degrade complex polysaccharides, play an important
Zheng Fu +5 more
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Frontiers in Microbiology, 2021 Hyaluronic acid (HA) is a negatively charged and linear polysaccharide existing in the tissues and body fluids of all vertebrates. Some pathogenic bacteria target hyaluronic acid for adhesion and/or infection to host cells.
Xiaoyi Wang +11 more
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Frontiers in Plant Science, 2022 Alginate (alginic acid) is a linear polysaccharide, wherein (1→4)-linked β-D-mannuronic acid and its C5 epimer, α-L-guluronic acid, are arranged in varying sequences.
Justyna M. Dobruchowska +9 more
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Genes for degradation and utilization of uronic acid-containing polysaccharides of a marine bacterium Catenovulum sp. CCB-QB4 [PDF]
PeerJ, 2021 Background Oligosaccharides from polysaccharides containing uronic acids are known to have many useful bioactivities. Thus, polysaccharide lyases (PLs) and glycoside hydrolases (GHs) involved in producing the oligosaccharides have attracted interest in ...
Go Furusawa +2 more
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Untangling the Reaction Mechanism of the Polysaccharide Lyase PL42 Using QM/MM Metadynamics Simulations. [PDF]
J Chem Inf ModelAlonso-Gil S +3 more
europepmc +2 more sources
Probing the pH Effects on Sugar Binding to a Polysaccharide Lyase [PDF]
The Journal of Physical Chemistry B, 2019 Polysaccharide lyases (PLs) are an important class of proteins that are excreted from bacteria to degrade sugars in the extracellular matrix of the host. The PL from S. maltophilia (Smlt1473) was found to have pH-specific degradation of three varying polysaccharides: alginate, celluronic acid, and hyaluronic acid (J. Biol. Chem. 2014, 289, 18022-18032).
Sook Wong +3 more
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Marine Drugs, 2022 Fucoidans represent a type of polyanionic fucose-containing sulfated polysaccharides (FCSPs) that are cleaved by fucoidan-degrading enzymes, producing low-molecular-weight fucoidans with multiple biological activities suitable for pharmacological use ...
Juanjuan Wang +7 more
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Phylogenetic Distribution of Polysaccharide-Degrading Enzymes in Marine Bacteria
Frontiers in Microbiology, 2021 Deconstruction is an essential step of conversion of polysaccharides, and polysaccharide-degrading enzymes play a key role in this process. Although there is recent progress in the identification of these enzymes, the diversity and phylogenetic ...
Zhong-Zhi Sun +12 more
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vAL‐1, a novel polysaccharide lyase encoded by chlorovirus CVK2 [PDF]
FEBS Letters, 2004 Cell wall materials isolated from Chlorella cells were degraded by the polysaccharide‐degrading enzyme vAL‐1 encoded by chlorovirus CVK2. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analyses of the degradation products (oligosaccharides) revealed major oligosaccharides contain unsaturated GlcA at the reducing terminus,
Sugimoto, Ichiro +4 more
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