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Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer
European Journal of Pharmaceutics and Biopharmaceutics, 2020Polysorbates are amphiphilic, non-ionic surfactants, and they represent one of the key components of biopharmaceuticals. They serve as stabilisers, and their degradation can cause particle formation, which has been an industry-wide issue over the past ...
Janez Mravljak, Stane Pajk
exaly +2 more sources
Rational design to biologics development: The polysorbates point of view
International Journal of Pharmaceutics, 2020Formulation development is an essential part of any biopharmaceuticals development programme, and this will affect quality, safety and efficacy of the final drug product.
Janez Mravljak, Stane Pajk
exaly +2 more sources
Journal of Pharmaceutical Sciences, 1978
Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature.
M, Donbrow, E, Azaz, A, Pillersdorf
exaly +3 more sources
Aqueous solutions of polysorbate 20 undergo autoxidation on storage, with the peroxide number increasing and subsequently decreasing again, the acidity increasing continuously, the pH and surface tension falling and tending to level off, and the cloud point dropping sharply until turbidity begins at room temperature.
M, Donbrow, E, Azaz, A, Pillersdorf
exaly +3 more sources
Journal of Chromatography A, 2020
Polysorbates, a group of nonionic surfactants, are widely used as pharmaceutic excipient. Their quality and safety are closely related to their profiles, including composition, structure, proportion and polyoxyethylene (POE) polymerization degree ...
Cai Tie, Jin-Lan Zhang
exaly +2 more sources
Polysorbates, a group of nonionic surfactants, are widely used as pharmaceutic excipient. Their quality and safety are closely related to their profiles, including composition, structure, proportion and polyoxyethylene (POE) polymerization degree ...
Cai Tie, Jin-Lan Zhang
exaly +2 more sources
Journal of Pharmaceutical Sciences, 1974
The CMC of a series of polysorbates was determined using a surface tension method. The CMC values obtained did not vary to any appreciable extent from those determined by other techniques, indicating that the procedure adopted was reliable, simple, and fast. The application of the usual correction factors was not necessary in the calculation of the CMC
L S, Wan, P F, Lee
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The CMC of a series of polysorbates was determined using a surface tension method. The CMC values obtained did not vary to any appreciable extent from those determined by other techniques, indicating that the procedure adopted was reliable, simple, and fast. The application of the usual correction factors was not necessary in the calculation of the CMC
L S, Wan, P F, Lee
exaly +3 more sources
How much can we trust polysorbates as food protein stabilizers - The case of bovine casein
Food Hydrocolloids, 2019Polysorbates are widely used in food and cosmetic products and pharmaceuticals for emulsion stabilization, preventing surface absorption and as stabilizers against protein aggregation.
Na Li, Yacine Hemar, Yang Sun
exaly +2 more sources
Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, 2018Polysorbates are commonly added to protein formulations and serve an important function as stabilizers. This paper reviews recent literature detailing some of the issues seen with the use of polysorbate 80 and polysorbate 20 in protein formulations.
Michael T. Jones +14 more
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The Characterization of Polysorbate
Current Protocols, 2022AbstractPolysorbates (PSs), including PS20 and PS80, are non‐ionic surfactants widely used in the pharmaceutical industry to enhance drug solubility and stability. Despite their wide application, PSs are prone to degradation by either hydrolysis or oxidation in drug formulations during storage; therefore, a PS characterization method assessing protein ...
Sisi, Zhang, Hui, Xiao, Ning, Li
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