Results 211 to 220 of about 9,191 (255)
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Stability of Biologics and the Quest for Polysorbate Alternatives
Trends in Biotechnology, 2021Most biopharmaceutical formulations use polysorbates: surfactants that are highly efficient but difficult to manage in terms of compositional variability, quality, and stability. Alternatives, such as poloxamers, albumin, and cyclodextrin, are becoming popular and are being explored for their potential to protect biopharmaceuticals against physical and
Sachin Dubey, Roberto Giovannini
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The determination of polysorbate 60 in foods
Journal of the American Oil Chemists' Society, 1971AbstractAnalytical methods have been developed for the determination of polysorbate 60 (Tween 60, Atlas Chemical Industries, Inc.) in several food products including baked bread and cake, cake mix, yeastraised doughnuts, shortening, foam‐mat dried tomato paste and citrus fruit juices, dressings for salad, and potato flakes.
C F, Smullin +2 more
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Journal of Chromatography A, 2019
Polysorbates are complex mixtures of over a thousand components with a wide range of hydrophobicity. This paper describes a methodology for characterization of heterogeneity and stability of polysorbates in therapeutic protein formulation.
Yan He +4 more
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Polysorbates are complex mixtures of over a thousand components with a wide range of hydrophobicity. This paper describes a methodology for characterization of heterogeneity and stability of polysorbates in therapeutic protein formulation.
Yan He +4 more
semanticscholar +1 more source
Analytical Biochemistry, 2019
Polysorbate 80, as pharmaceutical excipient and virus inactivating agent, is commonly used in the protein pharmaceutical industry. In this study, a method has been developed for the determination of low concentration of Polysorbate 80 in the presence of ...
Yongfeng Cheng +5 more
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Polysorbate 80, as pharmaceutical excipient and virus inactivating agent, is commonly used in the protein pharmaceutical industry. In this study, a method has been developed for the determination of low concentration of Polysorbate 80 in the presence of ...
Yongfeng Cheng +5 more
semanticscholar +1 more source
Challenges in polysorbate characterization by mass spectrometry
Rapid Communications in Mass Spectrometry, 2020Polysorbates are used in a variety of applications over a wide range of markets. Simple in concept, these products are complex in actual composition. Mass spectrometry and related techniques have been effectively used to characterize these products, from the major components to the minor residual production byproducts and degradation species.
Kevin W. Penfield, Stephen Rumbelow
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Pharmaceutical Research, 2002
Polysorbate 20 is a commonly used excipient in biopharmaceutical formulations, some of which may have an enzymatic activity. The action(s) of polysorbate 20 in biopharmaceutical formulations as a stabilizer require this surfactant to maintain its intact structure.
Mehrnaz, Khossravi +3 more
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Polysorbate 20 is a commonly used excipient in biopharmaceutical formulations, some of which may have an enzymatic activity. The action(s) of polysorbate 20 in biopharmaceutical formulations as a stabilizer require this surfactant to maintain its intact structure.
Mehrnaz, Khossravi +3 more
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Lonophoric Properties of Polysorbate 80
Journal of Pharmaceutical Sciences, 1986Polysorbate 80, a surfactant often assumed to be inert, was found to bind a number of biochemically important ions (K+, Na+, NH4+, Ca2+) and transport them through a model membrane (CH2Cl2). The rates and fluxes of potassium ions were found to depend on the initial concentration of potassium ion, the polysorbate 80 concentration, the temperature, and ...
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Polysorbate 80 and E-Ferol Toxicity
Pediatrics, 1986The relatively recent introduction and use of an intravenous form of a vitamin E preparation (E-Ferol) has been associated with the development of an unusual syndrome and fatalities among low birth weight (<1,500 g), premature infants in neonatal intensive care units.
S L, Alade, R E, Brown, A, Paquet
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Journal of Industrial and Engineering Chemistry, 2017
Abstract In the present study, binary mixed micelles of poloxamer 407 and a homologous series of polysorbate surfactants (polysorbate 20, polysorbate 60, polysorbate 80, polysorbate 85) were investigated. Rubingh’s model was applied to determine the physicochemical parameters of the poloxamer/polysorbate binary systems.
Dejan Ćirin +2 more
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Abstract In the present study, binary mixed micelles of poloxamer 407 and a homologous series of polysorbate surfactants (polysorbate 20, polysorbate 60, polysorbate 80, polysorbate 85) were investigated. Rubingh’s model was applied to determine the physicochemical parameters of the poloxamer/polysorbate binary systems.
Dejan Ćirin +2 more
openaire +1 more source