Results 201 to 210 of about 9,191 (255)

Industry perspective on the use and characterization of polysorbates for biopharmaceutical products Part 1: Survey report on current state and common practices for handling and control of polysorbates.

Journal of Pharmacy and Science, 2022
Polysorbates (PS) are widely used as a stabilizer in biopharmaceutical products. Industry practices on various aspects of PS are presented in this part 1 survey report based on a confidential survey and following discussions by 16 globally acting major ...
K. Wuchner, L. Yi, C. Chery, Felix Nikels, Friederike Junge, G. Crotts, Gianluca Rinaldi, Jason Starkey, Karoline Bechtold-Peters, Melissa Shuman, M. Leiss, M. Jahn, P. Garidel, Rien de Ruiter, Sarah M. Richer, S. Cao, Sebastian Peuker, S. Huille, Tingting Wangm Virginie Le Brun   +18 more
semanticscholar   +1 more source

Effect of different polysorbates on development of self-microemulsifying drug delivery systems using medium chain lipids

Drug Development and Industrial Pharmacy, 2018
Prajwal Thool
exaly   +2 more sources

Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80.

Molecular Pharmaceutics, 2021
Polysorbates (PSs, Tweens) are widely used surfactant products consisting of a sorbitan ring connecting up to four ethylene oxide (EO) chains of variable lengths, one or more of which are esterified with fatty acids of variable lengths and saturation ...
H. Knoch, Maximilian H. Ulbrich, Judith J. Mittag, J. Buske, P. Garidel, H. Heerklotz   +5 more
semanticscholar   +1 more source

Mechanism behind Polysorbates' Inhibitory Effect on P-Glycoprotein.

Molecular Pharmaceutics, 2022
Much effort has been invested in the search for modulators of membrane transport proteins such as P-glycoprotein (P-gp) to improve drug bioavailability and reverse multidrug resistance in cancer. Nonionic surfactants, a class of pharmaceutical excipients,
Laust Moesgaard, Peter Reinholdt, C. Nielsen, Jacob Kongsted   +3 more
semanticscholar   +1 more source

Acidic and alkaline hydrolysis of polysorbates under aqueous conditions: Towards understanding polysorbate degradation in biopharmaceutical formulations.

European Journal of Pharmaceutical Sciences, 2020
Polysorbate is one of the most commonly employed non-ionic surfactant in protein containing biological formulations, whereby, it can stabilize these biomolecules under different stress conditions.
Mridula Dwivedi, J. Buske, Frank Haemmerling, M. Blech, Garidel Patrick   +4 more
semanticscholar   +1 more source

Influence of polysorbates (Tweens) on structural and antimicrobial properties for microemulsions.

International journal of pharmaceutics, 2020
Polysorbates (Tweens) are one of the most used excipients for essential oils encapsulation. In this work, the polysorbate based microemulsions (PMEs) for R-(+)-limonene (LMN) encapsulation were investigated for the structural and antimicrobial properties.
Liang Guo, Ya-qian Fang, Xianrui Liang, Yu-yan Xu, Jie Chen, Yanhua Li, Sheng Fang, Yue-cheng Meng   +7 more
semanticscholar   +1 more source

Influence of surfactant hydrophobic segment length on the thermodynamic parameters of binary mixed micelles of homologues polysorbates and Triton X-100

Fluid Phase Equilibria, 2014
Mihalj M Poša, Dejan M Cirin
exaly   +2 more sources

The Composition of NF-Defined Emulsifiers: Sorbitan Monolaurate, Monopalmitate, Monostearate, Monooleate, Polysorbate 20, Polysorbate 40, Polysorbate 60, and Polysorbate 80

Drug Development and Industrial Pharmacy, 1998
Using the analytical constants for sorbitan monolaurate, monopalmitate, monostearate, and monooleate given in the National Formulary (NF), calculations were carried out that indicated that these emulsifiers are esters of sorbitol mono- and dianhydrides. Contrary to the NF description, no significant amount of sorbitol ester was calculated to be present,
openaire   +2 more sources

Inhalable polysorbates stabilized nintedanib nanocrystals to facilitate pulmonary nebulization and alveolar macrophage evasion.

Biomaterials Advances
Pulmonary delivery of nintedanib has noticeable advantages over the current oral administration in managing idiopathic pulmonary fibrosis (IPF). However, it remains a challenge to construct an efficient lung delivery system for insoluble nintedanib to ...
Huangliang Zheng, Jiaqi Li, S. Leung
semanticscholar   +1 more source

A Comparison of Polysorbates and Alternative Surfactants for Interfacial Stress Protection and Mitigation of Fatty Acid Particle Formation in the Presence of an Esterase.

Journal of Pharmacy and Science
The hydrolysis of polysorbate surfactants in large molecule drug product formulations caused by residual host cell proteins presents numerous stability concerns for pharmaceuticals.
I. Roy, K. Wuchner, P. Stahl, T. Tran, N. Yaragudi   +4 more
semanticscholar   +1 more source