Results 171 to 180 of about 313,059 (261)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Long-term Omega-3 polyunsaturated fatty acid supplementation improves meningeal lymphatic function during brain aging in mice. [PDF]

J Lipid Res
Liu Z, Peng J, Wang X, Yin F, Su F, Pei Z, Wu H, Luo C.   +7 more
europepmc   +1 more source

Polyunsaturated Fatty Acid Imbalance-A Contributor to SARS CoV-2 Disease Severity. [PDF]

J Nutr Metab
Chambers JP, Daum LT, Arulanandam BP, Valdes JJ.   +3 more
europepmc   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression. [PDF]

Redox Biol
Cao M, Li M, Li X, Li Y, Chen Y, Drekolia MK, Cheng X, Lagos FD, Bibli SI, Hu J.   +9 more
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Hepatic fatty acid profile and gut microbiome responses of ducks induced by dietary n-6/n-3 polyunsaturated fatty acid ratio. [PDF]

Poult Sci
Cao Z, Wang L, Zhang Y, Chang G, Chen G.
europepmc   +1 more source

Testing the feasibility of an intermittent low‐energy diet in women with gestational diabetes

Diabetic Medicine, EarlyView.
Abstract Aims The study aimed to assess feasibility, acceptability and safety of an ILED in a randomised controlled trial of ILED vs. best NHS care healthy diet and exercise advice in women with Gestational Diabetes Mellitus (GDM) with body mass index ≥27.5 kg/m2 (≥25 kg/m2 in high‐risk minority ethnic groups) in the last trimester of pregnancy ...
Elizabeth Dapre, Emma Barrett, Brian McMillan, Andrea Pilkington, Fahmy Hanna, Avni Vyas, Cheryl Lombardelli, Womba Mubita, Jessy Athirampuzha, Liveen Dosanjh, Michelle Harvie, Basil G. Issa   +11 more
wiley   +1 more source

Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis-Induced Osteoporosis in Mice. [PDF]

Metabolites
Liu X, Hu F, Zhang Y, Ma S, Liu H, Shang D, Yin P.   +6 more
europepmc   +1 more source

Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction‐associated steatohepatitis (MASH) and fibrosis. Recent clinical
Evangelia E. Tsakiridis, Gregory R. Steinberg   +1 more
wiley   +1 more source