Results 201 to 210 of about 20,745 (266)

Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice

Atherosclerosis, 2005
High density lipoprotein (HDL)-associated paraoxonase 1 (PON1), hydrolyzes oxidized lipids in oxidized low density lipoprotein (LDL) and thus protects against atherosclerosis development. Increased susceptibility to atherosclerosis observed in PON1 knockout (PON1(0)) mice was associated with increased LDL lipid peroxidation as well as increased ...
Orit, Rozenberg, Diana M, Shih, Michael, Aviram   +2 more
openaire   +2 more sources

The epigenetic regulation of paraoxonase 1 (PON1) as an important enzyme in HDL function: The missing link between environmental and genetic regulation.

Clinical Biochemistry, 2019
BACKGROUND Paraoxonase 1 (PON1) is an important antiatherogenic and antioxidant enzyme in the circulation that has been associated with adverse health outcomes particularly cardiovascular disease (CVD) and other metabolic disorders.
A. Mahrooz, M. Mackness, A. Bagheri, M. Ghaffari-Cherati, Parisa Masoumi   +4 more
semanticscholar   +1 more source

Genetic Polymorphism in Paraoxonase 1 (PON1): Population Distribution of PON1 Activity

Journal of Toxicology and Environmental Health, Part B, 2009
Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesting that human variability in PON1 needs to be considered in health risk assessments involving exposure to these ...
Gary, Ginsberg, Patricia, Neafsey, Dale, Hattis, Kathryn Z, Guyton, Douglas O, Johns, Babasaheb, Sonawane   +5 more
openaire   +2 more sources

The combined utility of myeloperoxidase (MPO) and paraoxonase 1 (PON1) as two important HDL-associated enzymes in coronary artery disease: Which has a stronger predictive role?

Atherosclerosis, 2019
BACKGROUND AND AIMS Serum paraoxonase 1 (PON1) and myeloperoxidase (MPO) are HDL-associated enzymes that contribute significantly to the formation of dysfunctional HDL.
A. Variji, Y. Shokri, S. Fallahpour, M. Zargari, B. Bagheri, S. Abediankenari, A. Alizadeh, A. Mahrooz   +7 more
semanticscholar   +1 more source

PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease

Immunology Letters, 2013
Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes.
Claudia, Huesca-Gómez, María Elena, Soto, Vicente, Castrejón-Téllez, Oscar, Pérez-Méndez, Ricardo, Gamboa   +4 more
openaire   +2 more sources

PON1 lactonase activity and its association with cardiovascular disease.

Clinica chimica acta; international journal of clinical chemistry, 2019
BACKGROUND Paraoxonase 1 (PON1) is important in the development of atherosclerosis, and it has become the subject of intensive research. Our aim was to evaluate the association of serum PON1 activity and polymorphisms with cardiovascular disease (CVD ...
F. Murillo-González, N. Ponce-Ruíz, A. Rojas-García, S. Rothenberg, Y. Y. Bernal-Hernández, R. Cerda-Flores, M. Mackness, B. Barrón-Vivanco, C. A. González-Arias, J. Ponce-Gallegos, I. Medina-Díaz   +10 more
semanticscholar   +1 more source

Modulation of paraoxonase (PON1) activity

Biochemical Pharmacology, 2005
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein (HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as well as nerve agents; it metabolizes toxic oxidized lipids associated with both low density lipoprotein (LDL) and HDL; and it can hydrolyze a number of lactone-containing ...
Lucio G. Costa, VITALONE, Annabella, Toby B. Cole, Clement E. Furlong   +3 more
openaire   +4 more sources

Association between PON1 5′-regulatory region polymorphisms, PON1 activity and ischemic stroke

Clinical Biochemistry, 2009
Paraoxonase I (PON1) was known as a risk factor for cerebrovascular diseases. This study assessed the association of single nucleotide polymorphisms (SNPs) in the PON1 5'-regulatory region with ischemic stroke and serum PON1 activity.Study subjects consisted of 418 healthy controls and 86 ischemic stroke patients with small vessel occlusion.
No Soo, Kim, Byoung Kab, Kang, Min Ho, Cha, Se-Mi, Oh, Mi Mi, Ko, Ok-Sun, Bang   +5 more
openaire   +2 more sources

Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease.

Clinical Biochemistry, 2018
INTRODUCTION Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the ...
M. Miljkovic, A. Stefanović, J. Vekić, A. Zeljković, T. Gojković, S. Simić-Ogrizović, N. Bogavac-Stanojević, D. Cerne, J. Ilić, I. Štefanović, Z. Jelić-Ivanović, V. Spasojević-Kalimanovska, J. Kotur-Stevuljević   +12 more
semanticscholar   +1 more source

Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model

Biomaterials, 2015
Dae-Won Kim, Kyu Hyung Han, Soo Young Choi   +2 more
exaly   +2 more sources