Results 211 to 220 of about 20,745 (266)

Paraoxonase 1 (PON1) status and substrate hydrolysis [PDF]

Toxicology and Applied Pharmacology, 2009
Paraoxonase 1 (PON1) hydrolyzes a number of organophosphorus (OP) compounds including insecticides and nerve agents. The in vivo efficacy of PON1 to protect against a specific OP exposure depends on the catalytic efficiency of hydrolysis. The Q192R polymorphism affects the catalytic efficiency of hydrolysis of some substrates and not others. While PON1(
Gail P. Jarvik, Clement E Furlong
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Pig PON1: Expression and promoter methylation

Gene Reports, 2018
Abstract Atherosclerosis is an inflammatory disease promoted by oxidized low density lipoprotein (LDL). High density lipoprotein (HDL) is an important antioxidant, protecting LDL and itself from oxidation and by detoxifying the hydroperoxides from oxidized LDL.
Larsen, Knud Erik, Farajzadeh, Leila, Kristensen, Kaja Kjaer   +2 more
openaire   +2 more sources

Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy

Reproductive Toxicology, 2012
The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon ...
Stefanović, Aleksandra, Ardalić, Daniela, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola   +9 more
openaire   +4 more sources

Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.

Clinica chimica acta; international journal of clinical chemistry, 2018
OBJECTIVE Genome studies have shown that the genes encoding paraoxonase 1 (PON1) and PON2 are associated with glucose metabolism. The goal of this study was to simultaneously evaluate the association between functional variants in PON1 and PON2 genes and
A. Mahrooz, M. Hashemi-Soteh, Masoud Heydari, Ruzbeh Boorank, F. Ramazani, A. Mahmoudi, Anvarsadat Kianmehr, A. Alizadeh   +7 more
semanticscholar   +1 more source

Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice

Free Radical Biology and Medicine, 2003
Human serum paraoxonase (PON1), an HDL-associated esterase, protects lipoproteins against oxidation, probably by hydrolyzing specific lipid peroxides. As arterial macrophages play a key role in oxidative stress in early atherogenesis, the aim of the present study was to examine the effect of PON1 on macrophage oxidative stress. For this purpose we used
Orit, Rozenberg, Mira, Rosenblat, Raymond, Coleman, Diana M, Shih, Michael, Aviram   +4 more
exaly   +3 more sources

Paraoxonase (Pon1) Q192R polymorphism and serum Pon1 activity in diabetic patients on maintenance hemodialysis

Clinical Nephrology, 2003
Patients with diabetic nephropathy have an increased risk of coronary heart disease (CHD). Paraoxonase (Pon1) is a high-density lipoprotein- (HDL) associated enzyme that protects low-density lipoprotein from oxidation and also protects against atherosclerosis.
B, Zhang, S, Eto, P, Fan, C, Bian, E, Shimoji, T, Saito, K, Saku   +6 more
openaire   +2 more sources

Macrophage paraoxonase 1 (PON1) binding sites

Biochemical and Biophysical Research Communications, 2008
Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study was to characterize macrophage PON1
Michal, Efrat, Michael, Aviram
openaire   +2 more sources

PON1 in Other Diseases

2002
HDL-associated paraoxonase (PON1) hydrolyses proinflammatory oxidized lipids, therefore blunting the inflammatory response. Increased oxidative stress leading to inflammation is involved in the etiology of several diseases, such as diabetes mellitus, atherosclerosis and a number of neurological disorders.
Bharti Mackness, Paul N. Durrington, Michael I. Mackness   +2 more
openaire   +1 more source

PON1 and Organophosphate Toxicity

2002
Early studies on different human populations showed that the hydrolytic activity of serum paraoxonase (PON1) was polymorphically distributed, raising the hypothesis that individuals with low PON1 activity may be at higher risk from toxic effects due to exposure to organophosphorus (OP) insecticides.
Lucio G. Costa, Wan-Fen Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, Clement E. Furlong   +5 more
openaire   +1 more source

Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status

Pharmacogenetics, 2003
Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik, Rachel, Jampsa, Rebecca J, Richter, Chris S, Carlson, Mark J, Rieder, Deborah A, Nickerson, Clement E, Furlong   +6 more
openaire   +2 more sources