Results 221 to 230 of about 20,745 (266)
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The PON1 gene and detoxication.
Neurotoxicology, 2001It has been assumed since its discovery that serum paraoxonase (PON1) plays a major role in the detoxication of specific organophosphorus compounds. It was also assumed that individuals with low PON1 activity would be more susceptible to paraoxon/parathion poisoning than individuals with higher PON1 activity.
Furlong, C. E +7 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry, 2008
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. This study
Hagai, Tavori +3 more
openaire +2 more sources
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. This study
Hagai, Tavori +3 more
openaire +2 more sources
2002
The initial research on serum paraoxonase (PON1) centered on its ability to hydrolyze arylesters such as phenylacetate organophosphorus and compounds such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups ...
Lucio G. Costa, Clement E. Furlong
openaire +1 more source
The initial research on serum paraoxonase (PON1) centered on its ability to hydrolyze arylesters such as phenylacetate organophosphorus and compounds such as paraoxon, from whence it received its name. Despite early evidence that paraoxon and phenylacetate were hydrolyzed by the same enzyme, it was many years before all of the various research groups ...
Lucio G. Costa, Clement E. Furlong
openaire +1 more source
Atherosclerosis, 2000
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele.
T, Suehiro +8 more
openaire +2 more sources
Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele.
T, Suehiro +8 more
openaire +2 more sources
Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis
Giornale Italiano di Dermatologia e Venereologia, 2019Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. Oxidative stress is considered to be a new etiopathogenetic key factor in the pathogenesis of psoriasis, as a result of the studies performing the association between psoriasis and paraoxonase 1 (PON1 ...
Akbas, Ali +8 more
openaire +3 more sources
2021
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openaire +1 more source
?????????????? ???????????????????? ?? 109 ?????????????????????? ???????????????? ?????????????? ??. ????????????????. ?????????????? ???????????? Q ???????? ???????????????????????? ?????????? ???????????????? ?????????????? ???????????????????? 0,67; ?????????????? ???????????? R ??? 0,33. ?????????????????????????? ?????????????????? ??????????????
openaire +1 more source
The active site of human paraoxonase (PON1)
Journal of Applied Toxicology, 2001Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1).
D, Josse +5 more
openaire +2 more sources
Paraoxonase 1 (PON1) reduces macrophage inflammatory responses
Atherosclerosis, 2013Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact on macrophage inflammatory responses, and the possible functional implications of such effects.Ex-vivo studies were performed with bone marrow-derived macrophages (BMDM) harvested from C57BL/6 and human-PON1 ...
Saar, Aharoni +2 more
exaly +3 more sources
2002
Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes.
Ronald Zech, Jörg M. Chemnitius
openaire +1 more source
Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes.
Ronald Zech, Jörg M. Chemnitius
openaire +1 more source