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Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs
Molecular Pharmaceutics, 2022While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of the barriers of conventional vehicles for the delivery of hydrophobic ...
Ridhdhi Dave +4 more
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Nanoprecipitation for Poorly Water-Soluble Drugs
Current Drug Metabolism, 2018More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.However, there are ...
Tuong N G, Nguyen +4 more
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Nanonization strategies for poorly water-soluble drugs
Drug Discovery Today, 2011Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen +4 more
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Hydrotropic Solubilization of Poorly Water-Soluble Drugs
Journal of Pharmaceutical Sciences, 2010The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope.
Ji Young, Kim +4 more
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Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration
Journal of Biomedical Nanotechnology, 2011Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir +6 more
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Drug Delivery Strategies for Poorly Water-Soluble Drugs: The Industrial Perspective
Expert Opinion on Drug Delivery, 2011For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Xiangli Liu, Peter van Hoogevest
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
Toxicologic Pathology, 2008More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues.
Elaine M, Merisko-Liversidge +1 more
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Pharmaceutical Methods for Enhancing the Dissolution of Poorly Water-Soluble Drugs
ASSAY and Drug Development Technologies, 2023Low water solubility is the main hindrance in the growth of pharmaceutical industry. Approximately 90% of newer molecules under investigation for drugs and 40% of novel drugs have been reported to have low water solubility. The key and thought-provoking task for the formulation scientists is the development of novel techniques to overcome the ...
Tahir Mahmood +4 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2011A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
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