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Nanonization strategies for poorly water-soluble drugs
Drug Discovery Today, 2011Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL).
Huabing, Chen +4 more
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Nanocrystallization of Poorly Water Soluble Drugs for Parenteral Administration
Journal of Biomedical Nanotechnology, 2011Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug.
Foziyah, Zakir +6 more
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Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions
Recent Patents on Drug Delivery & Formulation, 2013Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on ...
Thao T-D, Tran +4 more
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Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers
International Journal of Pharmaceutics, 2013A generic method is described to form poorly water-soluble drug nanoparticles within water-soluble porous polymer by solvent evaporation. The simple dissolution of porous polymer with drug nanoparticles results in stable aqueous drug nanoparticle suspension under the optimized conditions.
Aled D, Roberts, Haifei, Zhang
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Injectable Formulations of Poorly Water-Soluble Drugs
2011A growing number of new therapeutic molecules are limited by low or erratic bioavailability due to poor water solubility. Because of the clinical demand for new and more efficacious anti-cancer, antiviral, and anti-infective drugs, many of these new drugs must be formulated for injection. Poor water solubility can be addressed by a range of formulation
Michael P. Boquet, Dawn R. Wagner
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Drug delivery strategies for poorly water-soluble drugs: the industrial perspective
Expert Opinion on Drug Delivery, 2011For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the ...
Peter, van Hoogevest +2 more
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Injectable Formulations of Poorly Water-Soluble Drugs
2016Each year, an increasing number of new molecular entities are characterized as having poor water solubility. For parenteral formulations, it is exceptionally important that solubility limitations are well understood so that the desired therapeutic activity can be achieved.
Youssef W. Naguib +3 more
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Solubility Enhancement Techniques for Poorly Water-Soluble Drugs
International Journal of Pharmaceutical Sciences and Nanotechnology, 2017Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations ...
Amol S Deshmukh +2 more
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Transformation of acidic poorly water soluble drugs into ionic liquids
European Journal of Pharmaceutics and Biopharmaceutics, 2015Poor water solubility of active pharmaceutical ingredients (API) is a major challenge in drug development impairing bioavailability and therapeutic benefit. This study is addressing the possibility to tailor pharmaceutical and physical properties of APIs by transforming these into tetrabutylphosphonium (TBP) salts, including the generation of ionic ...
Anja Balk +5 more
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Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles
Nanoscale, 2016Various methods used to produce poorly water-soluble drug nanoparticles are reviewed, covering the fundamental, latest progress, and applications.
Ulrike, Wais +3 more
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