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Population Genetics and Pharmacogenetics [PDF]
, 2007 Genome-wide association studies (GWAS) have been hugely successful in identifying thousands of genetic loci robustly associated with hundreds of disease and other human traits. Since the first GWAS publication in an endocrinology-related topic, obesity in 2007, these studies have very rapidly increased in size and productivity. In 2011, this chapter is
Ken K. Ong, Cathy Elks
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Ecology and Evolution, 2019 Effective conservation and management of pond‐breeding amphibians depends on the accurate estimation of population structure, demographic parameters, and the influence of landscape features on breeding‐site connectivity.
Kyle A. O'Connell +4 more
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Genes Classical And Genes Developmental: The Different Uses Of The Gene In Evolutionary Synthesis [PDF]
, 2000 Dobzhansky (1964) stated that “Nothing in biology makes sense except in the light of evolution,” and the function of the gene is no exception. The use of genes in population genetics and developmental genetics differs significantly.
Gilbert, Scott F.
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Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
Nature Communications, 2022 The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.
Saaket Agrawal +15 more
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BMC Biology, 2022 Background Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determination and reversal.
Le Wang +15 more
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Population Genetics of Rare Variants and Complex Diseases [PDF]
, 2012 Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high throughput genome sequencing technologies is a central challenge faced by human geneticists today.
Hernandez, Ryan D. +3 more
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pegas: an R package for population genetics with an integrated-modular approach
Bioinform., 2010 SUMMARY pegas (Population and Evolutionary Genetics Analysis System) is a new package for the analysis of population genetic data. It is written in R and is integrated with two other existing R packages (ape and adegenet).
E. Paradis
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Population Genetics and Pharmacogenetics [PDF]
, 2005 The highlight for 2005/6 in population genetics was undoubtedly the publication of HapMap, a freely available public resource nearly of all common (>5% minor allele frequency) genetic differences in humans. Compared to the estimated 10 million single nucleotide polymorphisms (SNP) that we all share, at the launch of HapMap in 2002 there were fewer than
Heude, Barbara, Ong, Ken
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8 The population genetics of the haemoglobinopathies
Baillière's Clinical Haematology, 1993 The haemoglobinopathies are the commonest single gene disorders known, and are so common in some regions of the world that the majority of the population carries at least one genetic abnormality affecting the structure or synthesis of the haemoglobin molecule. The prevalence of the common haemoglobinopathies (the alpha- and beta-thalassaemias, HbS, HbC
Flint, J, Harding, R, Boyce, A, Clegg, J
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Neutral genomic signatures of host-parasite coevolution
BMC Evolutionary Biology, 2019 Background Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the ...
Daniel živković +4 more
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