Results 171 to 180 of about 14,560,391 (301)

Beta-PSMC: uncovering more detailed population history using beta distribution. [PDF]

BMC Genomics, 2022
Liu J, Ji X, Chen H.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Paleogenomics retraces the ancient population history of Southwestern East Asia for the past 12 000 years. [PDF]

Natl Sci Rev
Bai F, Zhang X, Fu Y, Lu H, Li F, Bennett EA, Pei S, Cao P, Dai Q, Liu F, Feng X, Zhang M, Wang W, Li F, Zhang G, Ping W, Liu T, Fu Q.   +17 more
europepmc   +1 more source

Genomics Reveals Complex Population History and Unexpected Diversity of Eurasian Otters (Lutra lutra) in Britain Relative to Genetic Methods. [PDF]

Mol Biol Evol, 2023
du Plessis SJ, Blaxter M, Koepfli KP, Chadwick EA, Hailer F.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Bony labyrinth morphology reveals deep population history and isolation among Homo sapiens in prehistoric northeastern Africa (44-3 ka). [PDF]

Nat Commun
Martin N, Velemínský P, Urciuoli A, Varadzinová L, Honegger M, Ambrose SH, Antoine D, Brandt SA, Brůžek J, Cauliez J, Duday H, Grine F, Brukner Havelková P, Irish JD, Jesse F, Maréchal L, Maureille B, Ribot I, Rmoutilova R, Rougier H, Santos F, Thibeault A, Usai D, Vanderesse N, Varadzin L, Whiting RJ, Crevecoeur I.   +26 more
europepmc   +1 more source

On the prospect of achieving accurate joint estimation of selection with population history. [PDF]

Genome Biol Evol, 2022
Johri P, Eyre-Walker A, Gutenkunst RN, Lohmueller KE, Jensen JD.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Whole-Genome Re-Sequencing Reveals Genetic Diversity and Population History of Arunachali Mithun (Bos frontalis). [PDF]

Int J Mol Sci
Chotso K, Rathore HS, Kumar H, Chamuah JK, Hanah SS, Shivanagowda GP.   +5 more
europepmc   +1 more source

Genomic Variation, Population History, and Long-Term Genetic Adaptation to High Altitudes in Tibetan Partridge (Perdix hodgsoniae). [PDF]

Mol Biol Evol, 2023
Palacios C, Wang P, Wang N, Brown MA, Capatosto L, Du J, Jiang J, Zhang Q, Dahal N, Lamichhaney S.   +9 more
europepmc   +1 more source