Developing an Evolutionary Baseline Model for Humans: Jointly Inferring Purifying Selection with Population History. [PDF]
Mol Biol Evol, 2023 Johri P, Pfeifer SP, Jensen JD.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Genomics Reveals Complex Population History and Unexpected Diversity of Eurasian Otters (Lutra lutra) in Britain Relative to Genetic Methods. [PDF]
Mol Biol Evol, 2023 du Plessis SJ +4 more
europepmc +1 more source
Population Growth Through History and the Escape from the Malthusian Trap [PDF]
, 1985 Artzrouni, Marc, Komlos, John
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Sex and size matter: Intricate dominance relationships in an East African large carnivore guild
EcosphereHuman disturbance has the potential to alter competitive interactions, favoring species better able to adapt to areas used by humans. One such species is the spotted hyena (Crocuta crocuta), which has been successful in human‐dominated areas throughout ...
Rasmus Worsøe Havmøller +3 more
doaj +1 more source
Exploratory analysis of multi-trait coadaptations in light of population history. [PDF]
Ecol Evol, 2022 Nakamichi R, Kitada S, Kishino H.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Population history and admixture of the Fulani people from the Sahel. [PDF]
Am J Hum GenetFortes-Lima CA +4 more
europepmc +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source