Results 161 to 170 of about 1,929,108 (262)

Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]

BMC Genomics, 2022
Nieto-Blázquez ME, Schreiber D, Mueller SA, Koch K, Nowak C, Pfenninger M.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The ecological niche and population history shape mosquito population genetics on a group of three Caribbean islands. [PDF]

Parasit Vectors
Helleman P, Schrama M, Trimbos KB, Braks MAH, Schaffner F, Stroo A, Wouters RM, van der Beek JG.   +7 more
europepmc   +1 more source

Genomic Insights Into the Population History and Biological Adaptation of Southwestern Chinese Hmong-Mien People. [PDF]

Front Genet, 2021
Liu Y, Xie J, Wang M, Liu C, Zhu J, Zou X, Li W, Wang L, Leng C, Xu Q, Yeh HY, Wang CC, Wen X, Liu C, He G.   +14 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Estimating the Distribution of Fitness Effects in Aye-Ayes (Daubentonia madagascariensis), Accounting for Population History as Well as Mutation and Recombination Rate Heterogeneity. [PDF]

Am J Primatol
Soni V, Versoza CJ, Pfeifer SP, Jensen JD.   +3 more
europepmc   +1 more source

Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria

, 2023
Martiniano R, Haber M, Almarri MA, Mattiangeli V, Kuijpers MCM, Chamel B, Breslin EM, Littleton J, Almahari S, Aloraifi F, Bradley DG, Lombard P, Durbin R.   +12 more
europepmc   +1 more source

Population history and genome wide association studies of birth weight in a native high altitude Ladakhi population. [PDF]

PLoS One, 2022
Bhandari S, Dolma P, Mukerji M, Prasher B, Montgomery H, Kular D, Jain V, Dadhwal V, Williams DJ, Bhattacharyaa A, Gilbert E, Cavalleri GL, Hillman SL.   +12 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cross-continental transmission and host adaptation of <i>Mycobacterium tuberculosis</i> in China unveiled by population history reconstruction and adaptive evolution signal detection. [PDF]

IMetaOmics
Wu W, Liu Z, Chen H, Tang Y, Jiang Z, Zhang Y, Zhang A, Zhou Z, Marks RS, Zhang F, Yuan H, Yu Y, Mao K, Dinnyés A, Rastogi N, Xie J, Sun Q.   +16 more
europepmc   +1 more source