Results 141 to 150 of about 2,115,565 (309)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
On the limits of fitting complex models of population history to f-statistics. [PDF]
Elife, 2023 Maier R +5 more
europepmc +1 more source
Young Feminist Organizing (YFO) Project video—Nawiri: Impact of YFOs
Globally and throughout history, young feminist activists have been a crucial part of feminist and social justice struggles in different settings and at different levels including the local, regional, and global levels.
Population Council Kenya
core
A multilevel event history analysis of the effects of grandmothers on child mortality in a historical German population (Krummhörn, Ostfriesland, 1720-1874) [PDF]
We analyzed data from the historic population of the Krummhörn (Ostfriesland, Germany, 1720-1874) to determine the effects of grandparents in general and grandmothers in particular on child mortality. Multilevel event-history models were used to test how
Eckart Voland, Jan Beise
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Population History Shapes Responses to Different Temperature Regimes in Drosophila subobscura. [PDF]
Life (Basel), 2023 Erić K +6 more
europepmc +1 more source
Young Feminist Organizing (YFO) Project video—Nawiri: Who and Why
Globally and throughout history, young feminist activists have been a crucial part of feminist and social justice struggles in different settings and at different levels including the local, regional, and global levels.
Population Council Kenya
core