Results 131 to 140 of about 1,929,108 (262)

Genomic Variation, Population History, and Long-Term Genetic Adaptation to High Altitudes in Tibetan Partridge (Perdix hodgsoniae). [PDF]

Mol Biol Evol, 2023
Palacios C, Wang P, Wang N, Brown MA, Capatosto L, Du J, Jiang J, Zhang Q, Dahal N, Lamichhaney S.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Recent population history in Swedish cattle breeds. [PDF]

Genet Sel Evol
Adepoju D, Ohlsson JI, Klingström T, Rius-Vilarrasa E, Johansson AM, Johnsson M.   +5 more
europepmc   +1 more source

On the prospect of achieving accurate joint estimation of selection with population history. [PDF]

Genome Biol Evol, 2022
Johri P, Eyre-Walker A, Gutenkunst RN, Lohmueller KE, Jensen JD.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Correction: Recent population history in Swedish cattle breeds. [PDF]

Genet Sel Evol
Adepoju D, Ohlsson JI, Klingström T, Rius-Vilarrasa E, Johansson AM, Johnsson M.   +5 more
europepmc   +1 more source

Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia. [PDF]

PLoS One, 2022
Askapuli A, Vilar M, Garcia-Ortiz H, Zhabagin M, Sabitov Z, Akilzhanova A, Ramanculov E, Schamiloglu U, Martinez-Hernandez A, Contreras-Cubas C, Barajas-Olmos F, Schurr TG, Zhumadilov Z, Flores-Huacuja M, Orozco L, Hawks J, Saitou N.   +16 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

At the Crossroads of Continents: Ancient DNA Insights into the Maternal and Paternal Population History of Croatia. [PDF]

Genes (Basel)
Marjanović D, Šarac J, Havaš Auguštin D, Novak M, Bašić Ž, Kružić I, Novokmet N, Cheronet O, Gelabert P, Pinhasi R, Lauc G, Primorac D.   +11 more
europepmc   +1 more source

Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history. [PDF]

Commun Biol, 2023
Silcocks M, Dunstan SJ.
europepmc   +1 more source