Results 131 to 140 of about 2,115,565 (309)

Genetic adaptations in the population history of Arabidopsis thaliana. [PDF]

G3 (Bethesda), 2023
Kishino H, Nakamichi R, Kitada S.
europepmc   +1 more source

The Long March of History: Farm Wages, Population and Economic Growth, England 1209-1869 [PDF]

The paper forms three series for English farm workers 1209-1869: nominal day wages, the implied marginal product of a day of farm labour, and the purchasing power of a days’ wage in terms of farm workers’ consumption.
Gregory Clark
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The reproductive value as part of the shadow price of population [PDF]

The reproductive value (see Fisher [10]) arises as part of the shadow price of the population in a large class of age-structured optimal control models.life history, reproductive ...
Michael Kuhn, Stefan Wrzaczek, Alexia Prskawetz, Gustav Feichtinger   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Decision-making for termination of pregnancy following non-invasive prenatal testing: a qualitative exploration of french, english and German healthcare professionals’ perceptions and concerns

Reproductive Health
Non-invasive prenatal testing (NIPT) is offered in the French, English and German public healthcare systems for fetal aneuploidy screening from a relatively early stage of pregnancy (around 10–12 weeks of gestation).
Adeline Perrot, Hilary Bowman-Smart, Tamar Nov-Klaiman, Ruth Horn   +3 more
doaj   +1 more source

Reconstructing the population history of the Sinhalese, the major ethnic group in Śrī Laṅkā. [PDF]

iScience, 2023
Singh PP, Kumar S, Pasupuleti N, Weerasooriya PR, van Driem G, Tennekoon KH, Rai N, Chaubey G, Ranasinghe R.   +8 more
europepmc   +1 more source

International migration in New Zealand: Context, components and policy issues

, 2000
This paper explores Aotearoa/New Zealand’s distinctive heritage as both a ‘traditional land of immigration’ as well as a ‘country of emigration’, with particular reference to contemporary policy issues and research initiatives. An underlying theme of the
Lidgard, Jacqueline, Ho, Elsie, Bedford, Richard   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source