Results 121 to 130 of about 2,115,565 (309)
Demographic change and transport needs in the Waikato region
, 2005 This report has been commissioned by Environment Waikato (EW) as part of its review of the Land Transport Strategy for the Waikato region. The report identifies key population characteristics that impact on transport needs of the EW region and the ...
Baxendine, Sandra +2 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Western Medicine in a Community in Ghana: A Social Change Review
Social Change Review, 2019 This study focuses on Western medical practices in the Atiwa District of Ghana. The people of Atiwa District accessed Western medicinal practice to prevent and cure diseases.
Adu-Gyamfi Samuel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Poverty, Population, Inequality, and Development: the Historical Perspective [PDF]
Seen in historical perspective the main economic predicaments of the present world (such as poverty, inequality, backwardness) appear in a somewhat different light than in many current discussions, especially by sociologists, radical economists and ...
Alberto Chilosi
core +2 more sources
Baseline Survey Instruments: Adolescent Girls Initiative–Kenya
, 2015 This document contains various AGI-K survey instruments, including: Household Characteristics Survey (English), Respondent’s Schooling History (English), Respondent’s Work in Last Year (English), Respondent’s Spending in Last Year (English), Respondent’s
Population Council
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Population and age structure [PDF]
, 2012 This paper provides a contemporary overview of the changing size and composition of Australia\u27s Indigenous population. The paper is structured around six key demographic and geographic features of the Indigenous population: Age structure: The ...
Nicholas Biddle
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source