Results 121 to 130 of about 16,226,702 (331)

Inference of Population History using Coalescent HMMs: Review and Outlook

, 2018
Studying how diverse human populations are related is of historical and anthropological interest, in addition to providing a realistic null model for testing for signatures of natural selection or disease associations.
Song, Yun S., Spence, Jeffrey P., Steinrücken, Matthias, Terhorst, Jonathan   +3 more
core  

Web of Failure: The Relationship Between Foster Care and Homelessness [PDF]

, 1995
The purpose of this project is to examine the connection between foster care and homelessness and to determine whether or not there is an over-representation of people with a foster care history in the homeless population. In order to examine this issue,
Nan P. Roman, Phyllis Wolfe
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Great ape genetic diversity and population history

Nature, 2013
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease.
Javier Prado-Martinez, Peter Sudmant, J. Kidd, Heng Li, Joanna L. Kelley, B. Lorente-Galdos, K. Veeramah, August E. Woerner, T. O’Connor, G. Santpere, A. Cagan, Christoph Theunert, F. Casals, H. Laayouni, Kasper Munch, A. Hobolth, Anders E. Halager, Maika Malig, Jessica Hernandez-Rodriguez, I. Hernando-Herraez, Kay Prüfer, M. Pybus, L. Johnstone, M. Lachmann, C. Alkan, D. Twigg, Natalia Petit, Carl A. Baker, F. Hormozdiari, Marcos Fernández-Callejo, M. Dabad, M. Wilson, L. Stevison, C. Camprubí, Tiago Carvalho, A. Ruiz-Herrera, Laura Vives, Marta Melé, Teresa Abelló, I. Kondova, R. Bontrop, A. Pusey, F. Lankester, John A. Kiyang, R. Bergl, E. Lonsdorf, S. Myers, M. Ventura, P. Gagneux, D. Comas, H. Siegismund, J. Blanc, Lidia Agueda-Calpena, M. Gut, L. Fulton, S. Tishkoff, J. Mullikin, R. Wilson, I. Gut, M. K. Gonder, O. Ryder, B. Hahn, A. Navarro, J. Akey, J. Bertranpetit, D. Reich, T. Mailund, M. Schierup, C. Hvilsom, A. Andrés, J. Wall, C. Bustamante, M. Hammer, E. Eichler, Tomàs Marquès-Bonet   +74 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Treating Tobacco Dependency in National Health Service Workers in Greater Manchester: An Evaluation of a Bespoke Digital Service

JTO Clinical and Research Reports
Introduction: Treating tobacco dependency in National Health Service (NHS) workers delivers substantial benefits at an individual, population, and health care system level.
Kavita Sivabalah, MB BCh BAO, MRCP (UK), David Crane, PhD, Samantha Neville, Mandy Hancock, MSc, Anthony Ryan, Bincy Ajay, Jane Coyne, BA, Elizabeth Benbow, Andrea Crossfield, MSc, Sebastian Bate, MMath, Matthew Evison, MD   +10 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tracking modern human population history from linguistic and cranial phenotype

Scientific Reports, 2016
Languages and genes arguably follow parallel evolutionary trajectories, descending from a common source and subsequently differentiating. However, although common ancestry is established within language families, it remains controversial whether language
H. Reyes-Centeno, K. Harvati, Gerhard Jäger   +2 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The population history of Garra orientalis (Teleostei: Cyprinidae) using mitochondrial DNA and microsatellite data with approximate Bayesian computation

BMC Evolutionary Biology, 2016
BackgroundThe South China landmass has been characterized by a complex geological history, including mountain lifting, climate changes, and river capture/reversal events.
Jin-Quan Yang, K. Hsu, Zhi-zhi Liu, Li-Wei Su, Po-Hsun Kuo, Wenqiao Tang, Zhuocheng Zhou, Dong Liu, B. Bao, Hung-Du Lin   +9 more
semanticscholar   +1 more source